| Autor: |
García-Cedrón D; Facultad de Ciencias de la Salud, Universidad César Vallejo, Trujillo 13001, Peru., De La Cruz Noriega M; Vicerrectorado de Investigación, Universidad Autónoma del Perú, Lima 15842, Peru., Cabanillas-Chirinos L; Instituto de Investigación en Ciencia y Tecnología, Universidad César Vallejo, Trujillo 13001, Peru., Otiniano NM; Instituto de Investigación en Ciencia y Tecnología, Universidad César Vallejo, Trujillo 13001, Peru., Rojas-Villacorta W; Programa de Investigación Formativa, Universidad César Vallejo, Trujillo 13001, Peru., Salvatierra-Espinola W; Facultad de Ciencias de la Salud, Universidad César Vallejo, Trujillo 13001, Peru., Del Aguila KD; Programa de Investigación Formativa, Universidad César Vallejo, Trujillo 13001, Peru., Luján-Velásquez M; Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Trujillo 13001, Peru. |
| Jazyk: |
angličtina |
| Zdroj: |
Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2023 Oct 03; Vol. 59 (10). Date of Electronic Publication: 2023 Oct 03. |
| DOI: |
10.3390/medicina59101763 |
| Abstrakt: |
Background and Objectives: In Peru, the presence of antimicrobial-resistant bacteria is a constant concern in hospitals and has likely increased in frequency during the pandemic. The objective of the study was to analyze the frequency of carbapenemase-producing bacteria resistant to two carbapenems (Imipenem and Meropenem), which were isolated from Peruvian patients in the intensive care unit of the Victor Lazarte Echegaray Hospital in Trujillo (Peru) during the COVID-19 pandemic. Materials and Methods: The biological samples of the patients hospitalized in the ICU were processed in the Microbiology Diagnostic Laboratory of the Víctor Lazarte Echegaray Hospital between May 2021 and March 2022. Antimicrobial sensitivity was determined with the automated system AutoScan-4, and for the identification of the type of carbapenemase, the RESISIT-3 O.K.N K-SET cassettes were used. Results: The results show that 76 cultures (76/129) had resistance to the two carbapenems (imipenem or meropenem), where the most frequent were Klebsiella pneuomoniae (31.6%), Pseudomonas aeruginosa (26.3%), and Acinetobacter baumannii (14.5%). Pseudomonas aeruginosa cultures showed at least three carbapenemase types (KPC, NDM, and OXA-48), while A. baumannii , Escherichia coli , and Burkholderia cepacia complex presented at least two carbapenemases (NDM and OXA-48). The carbapenemase NDM was detected in Enterobacter cloacae , Morganella morganii , and Proteus mirabilis , while KPC was present in all Klebsiella pneumoniae and Klebsiella oxytoca cultures. Conclusions : The samples from patients hospitalized in the Victor Lazarte Echegaray Hospital ICU showed a high prevalence of imipenem- and meropenem-resistant bacteria. These findings are relevant and concerning from the perspective of antibiotic-resistant bacteria monitoring, control, and disinfection. Thus, an appropriate antibiotic policy must be implemented. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
