Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus.

Autor:	Andriankaja OM; Center for Oral Health Research (COHR), University of Kentucky College of Dentistry, Lexington, KY 40536, USA., Adatorwovor R; College of Public Health, University of Kentucky, Lexington, KY 40536, USA., Kantarci A; The Forsyth Institute, Cambridge, MA 02142, USA., Hasturk H; Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA 02142, USA., Shaddox L; Center for Oral Health Research (COHR), University of Kentucky College of Dentistry, Lexington, KY 40536, USA., Levine MA; Center for Bone Health, Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2023 Oct 12; Vol. 11 (10). Date of Electronic Publication: 2023 Oct 12.
DOI:	10.3390/biomedicines11102770
Abstrakt:	Periodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM). Objectives: We assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults. Methods: We enrolled 248 Puerto Rican residents with T2DM aged 40-65 years. The exposures included serum inflammatory mediators (IL-1b, IL-6, IL-10, and TNF-α), endothelial adhesion molecules, RANKL levels, and the GCF content of these analytes from a subset of 158 samples. The outcomes included the percent of sites with a probing pocket depth (PPD) ≥ 4 mm and clinical attachment loss ≥ 4 mm. Adjusted logistic regression models were fit to the categorized outcomes. Results: Increased serum IL-10 (Adj. OR: 1.10, p = 0.04), sICAM-1 (Adj. OR: 1.01; p = 0.06), and elevated serum IL-1β (Adj. OR: 1.93; p = 0.06) were statistically significant or close to being significantly associated with a percent of sites with PPD ≥ 4 mm. An increase in GCF IL-1α (Adj. OR: 1.16; p < 0.01) and IL-1β (Adj: 2.40; p = 0.02) was associated with periodontal parameters. Conclusions: Our findings suggested that oral and systemic endothelial and inflammatory mediators are associated with periodontal clinical parameters among Hispanic adults with T2DM.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu