| Autor: |
Pinzaru AD; Department of Pediatrics, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Department of Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Mihai CM; Department of Pediatrics, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Department of Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Chisnoiu T; Department of Pediatrics, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Department of Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Pantazi AC; Department of Pediatrics, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania., Lupu VV; Department of Pediatrics, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Kassim MAK; Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania., Lupu A; Department of Pediatrics, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Grosan E; Department of Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Al Jumaili AZN; National Institute of Diabetes, Nutrition and Metabolic Diseases 'N.C. Paulescu', 020475 Bucharest, Romania., Ion I; Department of Pediatrics, Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.; Department of Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania., Stoleriu G; Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania., Ion I; Faculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania. |
| Abstrakt: |
The most common inherited condition that results in death, particularly in those of Caucasian heritage, is cystic fibrosis (CF). Of all the young adults diagnosed with cystic fibrosis, 20% will develop hyperglycemia as a complication, later classified as a disease associated with cystic fibrosis. Impaired insulin secretion and glucose intolerance represent the primary mechanisms associated with diabetes (type 1 or type 2) and cystic fibrosis. Oxidative stress represents the imbalance between oxygen-reactive species and antioxidant defense mechanisms. This pathogenic mechanism is vital in triggering other chronic diseases, including cystic fibrosis-related diabetes. It is essential to understand oxidative stress and the significant impact it has on CFRD. This way, therapies can be individually adjusted and tailored to each patient's needs. This review aims to understand the connection between CFRD and oxidative stress. As a subsidiary element, we analyzed the effects of glycemic balance on complications and their evolution over time, providing insights into their potential benefits in mitigating oxidative stress-associated complications. |
