Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease.

Autor:	Shin Y; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Han S; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Kwon J; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Ju S; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Choi TG; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Kang I; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Kim SS; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2023 Oct 21; Vol. 15 (20). Date of Electronic Publication: 2023 Oct 21.
DOI:	10.3390/nu15204466
Abstrakt:	The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles in a variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation of dietary fiber. Certain microbes in the gut are responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance in gut microbiome diversity can lead to metabolic disorders and inflammation-related diseases. Changes in SCFA levels and associated microbiota were observed in IBD, suggesting an association between SCFAs and disease. The gut microbiota and SCFAs affect reactive oxygen species (ROS) associated with IBD. Gut microbes and SCFAs are closely related to IBD, and it is important to study them further.
Databáze:	MEDLINE
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