Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis.
| Autor: | Ilieva H; Jefferson Weinberg ALS Center, Thomas Jefferson University, Philadelphia, PA, USA., Vullaganti M; Tufts University School of Medicine, Boston, Massachusetts, MA, USA., Kwan J; National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, USA justin.kwan@nih.gov. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | BMJ (Clinical research ed.) [BMJ] 2023 Oct 27; Vol. 383, pp. e075037. Date of Electronic Publication: 2023 Oct 27. |
| DOI: | 10.1136/bmj-2023-075037 |
| Abstrakt: | Although the past two decades have produced exciting discoveries in the genetics and pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy remains slow. This review summarizes the critical discoveries and outlines the advances in disease characterization, diagnosis, imaging, and biomarkers, along with the current status of approaches to ALS care and treatment. Additional knowledge of the factors driving disease progression and heterogeneity will hopefully soon transform the care for patients with ALS into an individualized, multi-prong approach able to prevent disease progression sufficiently to allow for a dignified life with limited disability. Competing Interests: Competing interests: We have read and understood the BMJ policy on declaration of interests and declare the following interests: none. (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|