Involvement of the posterior cingulate gyrus in temporal lobe epilepsy: A study using stereo-EEG.

Autor: Arévalo-Astrada MA; Division of Neurology, Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, 501 Smyth Box 511, Ottawa, Ontario K1H 8L6, Canada., Suller-Marti A; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada., McLachlan RS; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada., Paredes-Aragón E; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada., Jones ML; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada., Parrent AG; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada., Mirsattari SM; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada., Lau JC; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada., Steven DA; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada., Burneo JG; Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada; Neuro-Epidemiology Unit, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Rd. London, Ontario N6A 5A5, Canada. Electronic address: jburneo2@uwo.ca.
Jazyk: angličtina
Zdroj: Epilepsy research [Epilepsy Res] 2023 Dec; Vol. 198, pp. 107237. Date of Electronic Publication: 2023 Oct 10.
DOI: 10.1016/j.eplepsyres.2023.107237
Abstrakt: Objective: To analyze the involvement of the posterior cingulate gyrus (PCG) during mesial temporal lobe seizures (MTLS).
Methods: We retrospectively reviewed the stereo-EEG (SEEG) recordings of patients with MTLS performed in our institution from February 2013 to December 2020. Only patients who had electrode implantation in the PCG were included. Patients with lesions that could potentially alter the seizure spread pathways were excluded. We assessed the propagation patterns of MTLS with respect to the different structures sampled.
Results: Nine of 97 patients who had at least one seizure originating in the mesial temporal region met the inclusion criteria. A total of 174 seizures were analyzed. The PCG was the first site of propagation in most of the cases (8/9 patients and 77.5% of seizures, and 7/8 patients and 65.6% of seizures after excluding an outlier patient). The fastest propagation times were towards the contralateral mesial temporal region and ipsilateral PCG. Seven patients underwent standard anterior temporal lobectomy and, of these, all but one were Engel 1 at last follow up.
Conclusion: We found the PCG to be the first propagation site of MTLS in this group of patients. These results outline the relevance of the PCG in SEEG planning strategies. Further investigations are needed to corroborate whether fast propagation to the PCG predicts a good surgical outcome.
Competing Interests: Disclosure of interests Dr. Burneo holds the Jack Cowin Chair in Epilepsy Research from Western University. Dr. Mirsattari has received honorarium for speaking engagements for UCB Canada Inc., Eisai Co. Ltd (Canada), and Sunovion Pharmaceuticals Canada Inc. He has been member of the Epilepsy National Advisory Board for UCB Canada Inc., Eisai Co. Ltd (Canada) and Sunovion Pharmaceuticals Canada Inc. Dr. Steven receives educational funds from Livanova and receives speaker fees from UCB Canada and Medtronic Canada. Dr. Lee-Jones receives unrestricted educational grants from UCB and Sunovion. The remaining authors have no conflicts of interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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