Silences, spikes and bursts: Three-part knot of the neural code.

Autor: Friedenberger Z; Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Neural Dynamics and Artifical Intelligence, Department of Physics, University of Ottawa, Ottawa, Ontario, Ottawa., Harkin E; Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., Tóth K; Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada., Naud R; Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Neural Dynamics and Artifical Intelligence, Department of Physics, University of Ottawa, Ottawa, Ontario, Ottawa.
Jazyk: angličtina
Zdroj: The Journal of physiology [J Physiol] 2023 Dec; Vol. 601 (23), pp. 5165-5193. Date of Electronic Publication: 2023 Oct 27.
DOI: 10.1113/JP281510
Abstrakt: When a neuron breaks silence, it can emit action potentials in a number of patterns. Some responses are so sudden and intense that electrophysiologists felt the need to single them out, labelling action potentials emitted at a particularly high frequency with a metonym - bursts. Is there more to bursts than a figure of speech? After all, sudden bouts of high-frequency firing are expected to occur whenever inputs surge. The burst coding hypothesis advances that the neural code has three syllables: silences, spikes and bursts. We review evidence supporting this ternary code in terms of devoted mechanisms for burst generation, synaptic transmission and synaptic plasticity. We also review the learning and attention theories for which such a triad is beneficial.
(© 2023 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
Databáze: MEDLINE
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