Integrity of the nucleus basalis of meynert and self-reported cognitive dysfunction during wearing-off periods in parkinson's disease.

Autor: Lench DH; Department of Neurology, Medical University of South Carolina, 208-B Rutledge Ave, Charleston, SC, 29403, USA. lenchd@musc.edu., Turner TH; Department of Neurology, Medical University of South Carolina, 208-B Rutledge Ave, Charleston, SC, 29403, USA., Wetmore E; Department of Neurology, Medical University of South Carolina, 208-B Rutledge Ave, Charleston, SC, 29403, USA., Rodriguez-Porcel FJ; Department of Neurology, Medical University of South Carolina, 208-B Rutledge Ave, Charleston, SC, 29403, USA., Revuelta GJ; Department of Neurology, Medical University of South Carolina, 208-B Rutledge Ave, Charleston, SC, 29403, USA.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 Feb; Vol. 18 (1), pp. 256-261. Date of Electronic Publication: 2023 Oct 27.
DOI: 10.1007/s11682-023-00817-y
Abstrakt: Background: Cognition in Parkinson's Disease can be impacted by the wearing-off phenomenon which results from changes in dopaminergic tone throughout the day. Given the well-established role of the cholinergic basal forebrain in cognition, we hypothesized that the Nucleus Basalis of Meynert may support cognitive processes during wearing-off periods. Specifically, we evaluated whether worsening of cognitive symptoms during wearing-off is more likely to occur with structural degeneration of the Nucleus Basalis of Meynert.
Methods: Cognitive wearing-off was evaluated via the Movement Disorders Society Non-Motor Fluctuation Assessment Questionnaire in 33 Parkinson's Disease participants undergoing evaluation for deep brain stimulation. Pre-operative diffusion MRIs were used to measure brain diffusion metrics of the Nucleus Basalis of Meynert and control regions (caudate and putamen).
Results: The number of cognitive symptoms which worsened during OFF periods positively correlated with mean diffusivity (ρ = 0.561, p = 0.0007) and generalized fractional anisotropy (ρ=-0.447, p = 0.009) within the Nucleus Basalis of Meynert but not in the caudate or putamen. Meanwhile, stable cognitive symptoms, and ON-state cognitive performance as measured by the DRS-2 did not correlate with Nucleus Basalis of Meynert metrics. Correlations were corrected for age, sex, scanner type, disease duration, education and LEDD.
Conclusions: Our study suggests that reduced structural integrity of the Nucleus Basalis of Meynert is associated with worsening of participant-reported cognitive deficits during OFF periods, but not overall cognitive functioning in the ON-state. These findings support the hypothesis that structural integrity of the cholinergic Nucleus Basalis of Meynert may provide resilience to cognitive worsening during dopamine-related wearing-off.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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