Facile access to 5 H -thiazolo[2',3':2,3]imidazo[4,5- b ]indole derivatives by two-fold Cu-catalysed C-N coupling reactions.

Autor: Hung TQ; Institute of Chemistry, Vietnam Academy of Science and Technology, Viet Nam. tqhung@ich.vast.vn.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Viet Nam., Nguyen BCQ; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU), Viet Nam. dangthanhtuan@hus.edu.vn., Phuc BV; Institute of Chemistry, Vietnam Academy of Science and Technology, Viet Nam. tqhung@ich.vast.vn., Dang Van TD; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Viet Nam., Trang CM; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU), Viet Nam. dangthanhtuan@hus.edu.vn., Anh QTK; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU), Viet Nam. dangthanhtuan@hus.edu.vn., Do DV; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU), Viet Nam. dangthanhtuan@hus.edu.vn., Nguyen H; Faculty of Chemistry, Hanoi National University of Education (HNUE), Viet Nam., Ngo QA; Institute of Chemistry, Vietnam Academy of Science and Technology, Viet Nam. tqhung@ich.vast.vn.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Viet Nam., Dang TT; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU), Viet Nam. dangthanhtuan@hus.edu.vn.
Jazyk: angličtina
Zdroj: Organic & biomolecular chemistry [Org Biomol Chem] 2023 Nov 15; Vol. 21 (44), pp. 8813-8818. Date of Electronic Publication: 2023 Nov 15.
DOI: 10.1039/d3ob01515g
Abstrakt: In four simple steps, a series of 5 H -thiazolo[2',3':2,3]imidazo[4,5- b ]indole and 11 H -benzo[4',5']thiazolo[2',3':2,3]imidazo[4,5- b ]indole derivatives were prepared with high yields. The key step in this procedure was demonstrated to be two-fold Cu-catalysed C-N coupling reactions of 5-bromo-6-(2-bromophenyl)imidazo[2,1- b ]thiazole and 3-bromo-2-(2-bromophenyl)benzo[ d ]imidazo[2,1- b ]thiazole with various amines.
Databáze: MEDLINE