Transcending the challenge of evolving resistance mechanisms in Pseudomonas aeruginosa through β-lactam-enhancer-mechanism-based cefepime/zidebactam.

Autor:	Hujer AM; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Marshall SH; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA., Mack AR; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Hujer KM; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Bakthavatchalam YD; Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India., Umarkar K; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Palwe SR; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Takalkar S; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Joshi PR; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Shrivastava R; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Periasamy H; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Bhagwat SS; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Patel MV; Wockhardt Research Centre, Aurangabad, Maharashtra, India., Veeraraghavan B; Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India., Bonomo RA; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Departments of Pharmacology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, and the CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA.
Jazyk:	angličtina
Zdroj:	MBio [mBio] 2023 Dec 19; Vol. 14 (6), pp. e0111823. Date of Electronic Publication: 2023 Oct 27.
DOI:	10.1128/mbio.01118-23
Abstrakt:	Compared to other genera of Gram-negative pathogens, Pseudomonas is adept in acquiring complex non-enzymatic and enzymatic resistance mechanisms thus remaining a challenge to even novel antibiotics including recently developed β-lactam and β-lactamase inhibitor combinations. This study shows that the novel β-lactam enhancer approach enables cefepime/zidebactam to overcome both non-enzymatic and enzymatic resistance mechanisms associated with a challenging panel of P. aeruginosa . This study highlights that the β-lactam enhancer mechanism is a promising alternative to the conventional β-lactam/β-lactamase inhibitor approach in combating ever-evolving MDR P. aeruginosa . Competing Interests: Some of the coauthors are employees of Wockhardt. R.A.B. receives grant funding from Wockhardt.
Databáze:	MEDLINE
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