| Autor: |
Cheng MY; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Chuang YT; Department of Biomedical Science and Environmental Biology, PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Chang HW; Department of Biomedical Science and Environmental Biology, PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan., Lin ZY; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Chen CY; Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung 92641, Taiwan., Cheng YB; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. |
| Abstrakt: |
Five new eudensamane-type sesquiterpene lactones, clasamanes A-E ( 1 - 5 ), three new dolabellane-type diterpenes, clabellanes A-C ( 6 - 8 ), and fifteen known compounds ( 9 - 23 ) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components ( 1 - 8 ) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound 7 showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC 50 value of 7.26 ± 0.17 μg/mL. |
