Effect of Pharmaceutical Intervention in Pharmacologically Treated Hypertensive Patients-A Cluster-Randomized Clinical Trial: AFPRES-CLM Study.

Autor:	Luque Del Moral R; Pharmaceutical Care Research Group, University of Granada, 18011 Granada, Spain.; Council of Official Associations of Pharmaceutics of Castilla-La Mancha, 45005 Toledo, Spain.; Group of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, Campus de Ciencias de la Salud, 30120 Murcia, Spain., Gastelurrutia MA; Pharmaceutical Care Research Group, University of Granada, 18011 Granada, Spain., Martinez-Martinez F; Pharmaceutical Care Research Group, University of Granada, 18011 Granada, Spain., Jacomé JA; Pharmaceutical Care Foundation, 08017 Barcelona, Spain., Dago A; Pharmaceutical Care Foundation, 08017 Barcelona, Spain., Suarez B; Pharmaceutical Care Research Group, University of Granada, 18011 Granada, Spain.; Council of Official Associations of Pharmaceutics of Castilla-La Mancha, 45005 Toledo, Spain., Fikri-Benbrahim N; Pharmaceutical Care Research Group, University of Granada, 18011 Granada, Spain., Martí M; Pharmaceutical Care Foundation, 08017 Barcelona, Spain., Nuñez C; Group of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, Campus de Ciencias de la Salud, 30120 Murcia, Spain.; Murcia Research Institute of Health Sciences (IMIB), 30120 Murcia, Spain., Sierra-Alarcón S; Group of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, Campus de Ciencias de la Salud, 30120 Murcia, Spain.; Murcia Research Institute of Health Sciences (IMIB), 30120 Murcia, Spain., Fernandez-Gomez FJ; Group of Cellular and Molecular Pharmacology, Department of Pharmacology, CEIR Campus Mare Nostrum, University of Murcia, Campus de Ciencias de la Salud, 30120 Murcia, Spain.; Murcia Research Institute of Health Sciences (IMIB), 30120 Murcia, Spain.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2023 Oct 11; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 11.
DOI:	10.3390/jpm13101484
Abstrakt:	Background: Evaluate the effect of a community pharmaceutical intervention on the control of blood pressure in hypertensive patients treated pharmacologically. Methods: A cluster-randomized clinical trial of 6 months was carried out. It was conducted in the Autonomous Community of Castilla-La Mancha (Spain). Sixty-three community pharmacies and 347 patients completed the study. Intervention patients received the community pharmaceutical intervention based on a protocol that addresses the individual needs of each patient related to the control of their blood pressure, which included Health Education, Pharmacotherapy Follow-up and 24 h Ambulatory Blood Pressure Measurement. Control patients received usual care in the community pharmacy. Results: The pharmaceutical intervention resulted in better control of blood pressure (85.8% vs. 66.3% p < 0.001), lower use of emergencies ( p = 0.002) and improvement trends in the physical components of quality of life, measured by SF-36 questionnaire, after 6 months of pharmaceutical intervention. No significant changes were observed for any of these variables in the control group. There were also detected 354 negative medication-related outcomes that were satisfactorily resolved in a 74.9% of the cases and 330 healthcare education interventions and 29 Ambulatory Blood Pressure Monitorings were performed in order to increase adherence to pharmacological treatment and minimize Negative Outcomes associated with Medication and prevent medication-related problems. Conclusions: Community pharmaceutical intervention can increase hypertensive patients with controlled blood pressure, after 6 months, compared with usual care.
Databáze:	MEDLINE
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