| Autor: |
Soares NM; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., Barreto NMPV; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., Farias MMB; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., de Lima Oliveira C; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., Araújo WAC; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., de Souza JN; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., Teixeira MCA; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., Gonçalves NLS; Advanced Public Health Laboratory, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil., Sampaio DD; Brazil's Family Health Strategy, Municipal Health Department, Tremedal City Hall, Tremedal 45170-000, Bahia, Brazil., Pavan TBS; Advanced Public Health Laboratory, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil., Celedon PAF; Molecular Biology of Trypanosomatids Laboratory, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz-PR), Curitiba 81310-020, Paraná, Brazil., Zanchin NIT; Structural Biology and Protein Engineering Laboratory, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz-PR), Curitiba 81310-020, Paraná, Brazil.; Integrated Translational Program in Chagas Disease from Fiocruz (Fio-Chagas), Oswaldo Cruz Foundation (Fiocruz-RJ), Rio de Janeiro 21040-360, Rio de Janeiro, Brazil., Santos FLN; Advanced Public Health Laboratory, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador 40296-710, Bahia, Brazil.; Integrated Translational Program in Chagas Disease from Fiocruz (Fio-Chagas), Oswaldo Cruz Foundation (Fiocruz-RJ), Rio de Janeiro 21040-360, Rio de Janeiro, Brazil. |
| Abstrakt: |
Chagas disease (CD), caused by the parasite Trypanosoma cruzi , is a neglected tropical disease with life-threatening implications. In this study, we conducted a seroepidemiological survey to determine the prevalence and clinical profiles of CD in 217 individuals from an impoverished rural community in Southern Bahia, Brazil. The overall prevalence of CD in the studied community was 0.92%, detected through latent class analysis (LCA). Two individuals tested positive for anti- T. cruzi IgG, both being male farmers. One case was a 22-year-old man born in Camamu, with no evidence of congenital transmission, suggesting other routes of transmission such as vector-borne transmission due to migratory activities. The other case was a 69-year-old man born in São Felipe, who had lived in an adobe/brick house and had a pacemaker due to cardiac involvement caused by CD. The prevalence in this community was lower than expected, given the socioeconomic conditions and environmental factors that contribute to T. cruzi transmission. This could be attributed to the implementation of preventive measures and vector control programs by the Brazilian Government. However, continuous monitoring and surveillance are essential to sustain control efforts and detect any potential re-emergence of the disease. While the overall prevalence was low, the detection of positive cases underscores the need for continued surveillance and control measures in vulnerable populations, such as rural communities. Active surveillance, early diagnosis, and timely treatment are crucial in preventing disease progression and complications, thereby enhancing the effectiveness of screening and treatment programs. |
