Unraveling the Mysteries of Perineural Invasion in Benign and Malignant Conditions.

Autor: Bahmad HF; The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA., Gogola S; Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA., Rejzer M; Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA., Stoyanov K; Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA., Gomez AS; Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA., Valencia AK; Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA., Cummings A; Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA., Skerry T; Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA., Alloush F; The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA., Aljamal AA; Department of Medicine, Division of Hematology Oncology, Medical University of South Carolina, Charleston, SC 29425, USA., Deb A; The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA., Alghamdi S; The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.; Department of Pathology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA., Poppiti R; The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.; Department of Pathology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Jazyk: angličtina
Zdroj: Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Sep 30; Vol. 30 (10), pp. 8948-8972. Date of Electronic Publication: 2023 Sep 30.
DOI: 10.3390/curroncol30100647
Abstrakt: Perineural invasion (PNI) is defined as the dissemination of neoplastic cells within the perineural space. PNI can be a strong indicator of malignancy and is linked to poor prognosis and adverse outcomes in various malignant neoplasms; nevertheless, it can also be seen in benign pathologic conditions. In this review article, we discuss various signaling pathways and neurotrophic factors implicated in the development and progression of PNI. We also describe the methodology, benefits, and limitations of different in vitro, ex vivo, and in vivo models of PNI. The spectrum of presentation for PNI can range from diffuse spread within large nerves ("named" nerves) all the way through localized spread into unnamed microscopic nerves. Therefore, the clinical significance of PNI is related to its extent rather than its mere presence or absence. In this article, we discuss the guidelines for the identification and quantification of PNI in different malignant neoplasms based on the College of American Pathologists (CAP) and World Health Organization (WHO) recommendations. We also describe benign pathologic conditions and neoplasms demonstrating PNI and potential mimics of PNI. Finally, we explore avenues for the future development of targeted therapy options via modulation of signaling pathways involved in PNI.
Databáze: MEDLINE
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