| Autor: |
Artini M; Department of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, Italy., Papa R; Department of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, Italy., Vrenna G; Department of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, Italy.; Research Unit of Diagnostical and Management Innovations, Children's Hospital and Institute Research Bambino Gesù, 00165 Rome, Italy., Trecca M; Department of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, Italy., Paris I; Department of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, Italy., D'Angelo C; Department of Chemical Sciences, Federico II University, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy., Tutino ML; Department of Chemical Sciences, Federico II University, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy., Parrilli E; Department of Chemical Sciences, Federico II University, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy., Selan L; Department of Public Health and Infectious Diseases, Sapienza University, p.le Aldo Moro 5, 00185 Rome, Italy. |
| Abstrakt: |
The ESKAPE pathogens, including bacteria such as Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter species, pose a global health threat due to their ability to resist antimicrobial drugs and evade the immune system. These pathogens are responsible for hospital-acquired infections, especially in intensive care units, and contribute to the growing problem of multi-drug resistance. In this study, researchers focused on exploring the potential of Antarctic marine bacteria as a source of anti-biofilm molecules to combat ESKAPE pathogens. Four Antarctic bacterial strains were selected, and their cell-free supernatants were tested against 60 clinical ESKAPE isolates. The results showed that the supernatants did not exhibit antimicrobial activity but effectively prevented biofilm formation and dispersed mature biofilms. This research highlights the promising potential of Antarctic bacteria in producing compounds that can counteract biofilms formed by clinically significant bacterial species. These findings contribute to the development of new strategies for preventing and controlling infections caused by ESKAPE pathogens. |
