| Autor: |
Martini CL; Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil., Silva DNS; Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil., Viana AS; Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil., Planet PJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19106, USA., Figueiredo AMS; Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.; Programa de Pós-graduação em Patologia, Faculdade de Medicina, Universidade Federal, Fluminense, Niterói 24220-900, RJ, Brazil., Ferreira-Carvalho BT; Departamento de Microbiologia Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil. |
| Abstrakt: |
Streptococcus pyogenes is known to be associated with a variety of infections, from pharyngitis to necrotizing fasciitis (flesh-eating disease). S. pyogenes of the ST62/ emm 87 lineage is recognized as one of the most frequently isolated lineages of invasive infections caused by this bacterium, which may be involved in hospital outbreaks and cluster infections. Despite this, comparative genomic and phylogenomic studies have not yet been carried out for this lineage. Thus, its virulence and antimicrobial susceptibility profiles are mostly unknown, as are the genetic relationships and evolutionary traits involving this lineage. Previously, a strain of S. pyogenes ST62/ emm 87 (37-97) was characterized in our lab for its ability to generate antibiotic-persistent cells, and therapeutic failure in severe invasive infections caused by this bacterial species is well-reported in the scientific literature. In this work, we analyzed genomic and phylogenomic characteristics and evaluated the virulence and resistance profiles of ST62/ emm 87 S. pyogenes from Brazil and international sources. Here we show that strains that form this lineage (ST62/ emm 87) are internationally spread, involved in invasive outbreaks, and share important virulence profiles with the most common emm types of S. pyogenes , such as emm 1, emm 3, emm 12, and emm 69, which are associated with most invasive infections caused by this bacterial species in the USA and Europe. Accordingly, the continued increase of ST62/ emm 87 in severe S. pyogenes diseases should not be underestimated. |
