Ultraviolet light spectroscopic characterization of ibuprofen acid aggregation in deionized water.
| Autor: | Marbán G; Instituto de Ciencia y Tecnología del Carbono (INCAR-CSIC), c/Francisco Pintado Fe 26, 33011, Oviedo, Spain., Fernández-Pérez A; Instituto de Ciencia y Tecnología del Carbono (INCAR-CSIC), c/Francisco Pintado Fe 26, 33011, Oviedo, Spain., Álvarez-García S; Departamento de Ingeniería Química y Tecnología del Medio Ambiente, Facultad de Químicas, Universidad de Oviedo, c/Julián Clavería 8, 33006, Oviedo, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2023 Oct 20; Vol. 9 (11), pp. e21260. Date of Electronic Publication: 2023 Oct 20 (Print Publication: 2023). |
| DOI: | 10.1016/j.heliyon.2023.e21260 |
| Abstrakt: | This work provides a description of the aggregation equilibria of ibuprofen acid in deionized water at temperatures between 20 and 40 °C in the 0.1-20.1 ppm concentration range. For this goal, we have made use of UV-Visible spectroscopy. A calculation algorithm was developed to obtain the aggregate orders and thermodynamic parameters from the experimental absorbance values. Monomeric ibuprofen acid was found to be absent in water solutions. In addition to the dimer, two aggregates formed by 32 and 128 monomeric units were found to co-exist in solution at the highest concentration tested. A critical micelle concentration of 7.8 ppm was estimated for this system. The appearance of the first aggregate occurs when the pH drops below the pK Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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