Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination.

Autor: Mitsi E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. elena.mitsi@paediatrics.ox.ac.uk.; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK. elena.mitsi@paediatrics.ox.ac.uk., Diniz MO; Division of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK., Reiné J; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Collins AM; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Robinson RE; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Hyder-Wright A; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Farrar M; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Liatsikos K; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Hamilton J; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Onyema O; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Urban BC; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Solórzano C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK., Belij-Rammerstorfer S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Sheehan E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Lambe T; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Draper SJ; Department of Biochemistry, University of Oxford, Oxford, UK., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, USA., Maini MK; Division of Infection and Immunity and Institute of Immunity and Transplantation, UCL, London, UK., Ferreira DM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. daniela.ferreira@paediatrics.ox.ac.uk.; Department of Clinical Science, Liverpool School of Tropical Medicine, Liverpool, UK. daniela.ferreira@paediatrics.ox.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Oct 26; Vol. 14 (1), pp. 6815. Date of Electronic Publication: 2023 Oct 26.
DOI: 10.1038/s41467-023-42433-w
Abstrakt: Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, the capacity of peripheral vaccination to generate sustained immunity in the lung mucosa, and how this is influenced by prior SARS-CoV-2 infection, is unknown. Here we show using bronchoalveolar lavage samples that donors with history of both infection and vaccination have more airway mucosal SARS-CoV-2 antibodies and memory B cells than those only vaccinated. Infection also induces populations of airway spike-specific memory CD4+ and CD8+ T cells that are not expanded by vaccination alone. Airway mucosal T cells induced by infection have a distinct hierarchy of antigen specificity compared to the periphery. Spike-specific T cells persist in the lung mucosa for 7 months after the last immunising event. Thus, peripheral vaccination alone does not appear to induce durable lung mucosal immunity against SARS-CoV-2, supporting an argument for the need for vaccines targeting the airways.
(© 2023. The Author(s).)
Databáze: MEDLINE
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