Beyond energy and growth: the role of metabolism in developmental signaling, cell behavior and diapause.
| Autor: | Tippetts TS; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Sieber MH; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Solmonson A; Laboratory of Developmental Metabolism and Placental Biology, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Development (Cambridge, England) [Development] 2023 Oct 15; Vol. 150 (20). Date of Electronic Publication: 2023 Oct 26. |
| DOI: | 10.1242/dev.201610 |
| Abstrakt: | Metabolism is crucial for development through supporting cell growth, energy production, establishing cell identity, developmental signaling and pattern formation. In many model systems, development occurs alongside metabolic transitions as cells differentiate and specialize in metabolism that supports new functions. Some cells exhibit metabolic flexibility to circumvent mutations or aberrant signaling, whereas other cell types require specific nutrients for developmental progress. Metabolic gradients and protein modifications enable pattern formation and cell communication. On an organism level, inadequate nutrients or stress can limit germ cell maturation, implantation and maturity through diapause, which slows metabolic activities until embryonic activation under improved environmental conditions. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2023. Published by The Company of Biologists Ltd.) |
| Databáze: | MEDLINE |
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