L. plantarum and L. lactis as a promising agent in treatment of inflammatory bowel disease and colorectal cancer.

Autor: Javid H; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 1313199137, Iran.; Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, 917966679, Iran., Oryani MA; Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 1313199137, Iran., Akbari S; Department of Biology, Islamic Azad University, Mashhad Branch, Mashhad, 9133736351, Iran., Amiriani T; Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, 4918936316, Iran., Ravanbakhsh S; Biology Expert, Plant Sciences, graduate of Golestan University, Gorgan, 4918936316, Iran., Rezagholinejad N; Department of Biochemistry, Payame Noor University (PNU), Mashhad, 193954697, Iran., Afshari AR; Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 9414974877, Iran., Karimi-Shahri M; Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 1313199137, Iran.; Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, 9691657678, Iran.
Jazyk: angličtina
Zdroj: Future microbiology [Future Microbiol] 2023 Nov; Vol. 18, pp. 1197-1209. Date of Electronic Publication: 2023 Oct 26.
DOI: 10.2217/fmb-2023-0076
Abstrakt: It has been understood for nearly a century that patients with intestinal inflammatory disease (IBD) have a higher risk of developing colorectal cancer (CRC). Recently, two species of lactic acid bacteria, Lactobacillus plantarum and Lactococcus lactis , have been investigated as therapeutic agents for IBD. These bacteria have been shown to survive gastric transit, to adhere and colonize in the intestinal tract of humans and modulate the intestinal microbiota and immune response. L. plantarum and L. lactis might be used as multifunctional drugs for the treatment of IBD and the prevention or treatment of CRC. This article summarizes current knowledge of L. plantarum and L. lactis as therapeutic and preventative agents for IBD and CRC, respectively.
Databáze: MEDLINE