Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection.

Autor:	Lu L-F; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; University of Chinese Academy of Sciences , Beijing, China., Li Z-C; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; University of Chinese Academy of Sciences , Beijing, China., Zhang C; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; University of Chinese Academy of Sciences , Beijing, China., Chen D-D; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; University of Chinese Academy of Sciences , Beijing, China., Han K-J; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; College of Fisheries and Life Science, Dalian Ocean University , Dalian, China., Zhou X-Y; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; University of Chinese Academy of Sciences , Beijing, China., Wang X-L; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; College of Fisheries and Life Science, Dalian Ocean University , Dalian, China., Li X-Y; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; University of Chinese Academy of Sciences , Beijing, China.; State Key Laboratory of Freshwater Ecology and Biotechnology, The Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Hubei Hongshan Laboratory, the Innovation Academy of Seed Design, Chinese Academy of Sciences , Wuhan, China., Zhou L; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; University of Chinese Academy of Sciences , Beijing, China.; State Key Laboratory of Freshwater Ecology and Biotechnology, The Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Hubei Hongshan Laboratory, the Innovation Academy of Seed Design, Chinese Academy of Sciences , Wuhan, China., Li S; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.; University of Chinese Academy of Sciences , Beijing, China.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2023 Nov 30; Vol. 97 (11), pp. e0143423. Date of Electronic Publication: 2023 Oct 26.
DOI:	10.1128/jvi.01434-23
Abstrakt:	Importance: Mitochondrial antiviral signaling protein (MAVS) and stimulator of interferon (IFN) genes (STING) are key adaptor proteins required for innate immune responses to RNA and DNA virus infection. Here, we show that zebrafish transmembrane protein 47 (TMEM47) plays a critical role in regulating MAVS- and STING-triggered IFN production in a negative feedback manner. TMEM47 interacted with MAVS and STING for autophagic degradation, and ATG5 was essential for this process. These findings suggest the inhibitory function of TMEM47 on MAVS- and STING-mediated signaling responses during RNA and DNA virus infection. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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