A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells.

Autor:	Khan A; Bionanotechnology Lab, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh, India. akoner@iiserb.ac.in., Meena VK; Bionanotechnology Lab, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh, India. akoner@iiserb.ac.in., Silswal A; Bionanotechnology Lab, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh, India. akoner@iiserb.ac.in., Koner AL; Bionanotechnology Lab, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh, India. akoner@iiserb.ac.in.
Jazyk:	angličtina
Zdroj:	The Analyst [Analyst] 2023 Nov 20; Vol. 148 (23), pp. 5851-5855. Date of Electronic Publication: 2023 Nov 20.
DOI:	10.1039/d3an01469j
Abstrakt:	Peroxynitrite (ONOO - ), a highly reactive species, plays a key role in various physiological and pathological processes. Herein, a red-emitting fluorescent reporter perylenemonoimide-boronate ester (PMI-BE) was synthesized and utilized for ultrasensitive detection of ONOO - . The unique feature of PMI-BE is its nanomolar sensitivity with high selectivity towards ONOO - . Moreover, PMI-BE also detects endogenously generated ONOO - in live cells.
Databáze:	MEDLINE
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