Influence of different time framings, reconstruction algorithms and post-processing methods on the quantification of myocardial blood flow from 13 N-NH 3 PET images.

Autor: Akil S; Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden., Székely AE; Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden., Hedeer F; Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden., Olsson B; Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden., Engblom H; Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden., Hindorf C; Department of Medical Radiation Physics, Lund University, Lund, Sweden.
Jazyk: angličtina
Zdroj: Clinical physiology and functional imaging [Clin Physiol Funct Imaging] 2024 Mar; Vol. 44 (2), pp. 154-163. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1111/cpf.12861
Abstrakt: Background: The aim was to investigate to what extent the quantification of myocardial blood flow (MBF) from dynamic 13 N-NH 3 positron emission tomography (PET) images is affected by time frame schemes, time-of-flight (ToF), reconstruction algorithms, blood pool volume of interest (VOI) locations and compartment models in patients with suspected chronic coronary syndrome.
Methods: A standard MBF value was determined from 25 patients' rest/stress 13 N-NH 3 PET/CT images reconstructed with ordered subset expectation maximization (OSEM), 5 s time frame for the first frames without ToF, subsequently analyzed using a basal VOI and the deGrado compartment model. MBFs calculated using 2 or 10 s for the first frames, ToF, block-sequential regularized expectation maximization (BSREM), apical or large VOI, Hutchins or Krivokapich compartment models were compared to MBF standard in Bland-Altman plots (bias ± SD).
Results: Good agreement in global rest/stress MBF (mL/min/g) was found when changing the time frame scheme or reconstruction algorithm (MBF standard vs. MBF 2s : -0.02 ± 0.06; MBF 10s : 0.01 ± 0.07; MBF BSREM : 0.01 ± 0.07), while a lower level of agreement was found when altering the other factors (MBF standard vs. MBF ToF : -0.07 ± 0.10; MBF apical VOI : -0.27 ± 0.25; MBF large VOI : -0.11 ± 0.10; MBF Hutchins : -0.08 ± 0.10; MBF Krivokapich : -0.47 ± 0.50).
Conclusions: Quantification of MBF from 13 N-NH 3 PET images is more affected by choice of compartment models, ToF and blood pool VOIs than by different time frame schemes and reconstruction algorithms.
(© 2023 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.)
Databáze: MEDLINE
Externí odkaz: