Correlation between L-amino acid transporter 1 expression and 4-borono-2- 18 F-fluoro-phenylalanine accumulation in humans.

Autor: Kashihara T; Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.; Division of Research and Development for Boron Neutron Capture Therapy, National Cancer Center Exploratory Oncology Research & Clinical Trial Center, Tokyo, Japan., Mori T; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan., Nakaichi T; Division of Research and Development for Boron Neutron Capture Therapy, National Cancer Center Exploratory Oncology Research & Clinical Trial Center, Tokyo, Japan.; Department of Medical Physics, National Cancer Center Hospital, Tokyo, Japan., Nakamura S; Division of Research and Development for Boron Neutron Capture Therapy, National Cancer Center Exploratory Oncology Research & Clinical Trial Center, Tokyo, Japan.; Department of Medical Physics, National Cancer Center Hospital, Tokyo, Japan., Ito K; Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan., Kurihara H; Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.; Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Yokohama, Japan., Kusumoto M; Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan., Itami J; Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.; Shin-Matsudo Accuracy Radiation Therapy Center, Shin-Matsudo Central General Hospital, Chiba, Japan., Yoshimoto S; Department of Head and Neck Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan., Igaki H; Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.; Division of Research and Development for Boron Neutron Capture Therapy, National Cancer Center Exploratory Oncology Research & Clinical Trial Center, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2023 Nov; Vol. 12 (21), pp. 20564-20572. Date of Electronic Publication: 2023 Oct 25.
DOI: 10.1002/cam4.6635
Abstrakt: Background: The correlation between L-type amino acid transporter 1 (LAT1) expression and 4-borono-2- 18 F-fluoro-phenylalanine ( 18 F-FBPA) accumulation in humans remains unclear. This study aimed to investigate the correlation between LAT1 expression in tumor tissues and 18 F-FBPA accumulation in patients with head and neck cancer who participated in a clinical trial of 18 F-FBPA positron emission tomography (PET).
Methods: Altogether, 28 patients with head and neck cancer who participated in a clinical trial of 18 F-FBPA PET at our institution between March 2012 and January 2018 were included. Correlations between standardized uptake values (SUVs); the maximum SUV (SUV max ), the mean SUV within a 1 cm 3 sphere centered at a single point, that is, the SUV max (SUV peak ), the minimum SUV (SUV min ), and the intensity of LAT1 expression (maximum and minimum LAT1 expressions) were investigated.
Results: Weak correlations were identified between SUV max and LAT1 maximum score, SUV min and LAT1 maximum score, and SUV min and LAT1 minimum score (ρ = 0.427, 0.362, and 0.330, respectively). SUV max and LAT1 minimum score, SUV peak and LAT1 maximum score, and SUV peak and LAT1 minimum score demonstrated moderate correlations (ρ = 0.535, 0.556, and 0.661, respectively). Boron neutron capture therapy (BNCT) was performed in 2 of the 4 patients with discrepancies between 18 F-FBPA accumulation and intensity of LAT1 expression, and the intensity of LAT1 expression was a better predictor of treatment response.
Conclusion: 18 F-FBPA accumulation and the intensity of LAT1 expression demonstrated a moderate correlation; however, LAT1 expression may be a better predictor of treatment response of BNCT in patients with discrepancies.
(© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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