Thiamine Responsive Acute Infantile Encephalopathy.

Autor: Gurung B; Department of Pediatrics, Sir Thutob Namgyal Memorial Hospital, Gangtok, Sikkim, 737101, India., Bhutia TD; Department of Pediatrics, Sir Thutob Namgyal Memorial Hospital, Gangtok, Sikkim, 737101, India. tsuld@yahoo.com.; Department of Pediatrics, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India. tsuld@yahoo.com., Chettri S; Department of Pediatrics, Sir Thutob Namgyal Memorial Hospital, Gangtok, Sikkim, 737101, India.; Department of Pediatrics, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India., Mummadi MK; Clinical Epidemiology Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana, India., Bondre VP; Encephalitis Group, ICMR- National Institute of Virology, Pune, Maharashtra, India.
Jazyk: angličtina
Zdroj: Indian journal of pediatrics [Indian J Pediatr] 2024 Sep; Vol. 91 (9), pp. 964-966. Date of Electronic Publication: 2023 Oct 26.
DOI: 10.1007/s12098-023-04889-y
Abstrakt: This retrospective study was conducted to describe clinical and investigational findings and to determine the effect of thiamine treatment on mortality in patients admitted with acute non-infectious encephalopathy to a hospital in Sikkim between October 2019 and March 2021. Amongst 37 included patients the median age was 4 mo (IQR 3-5), 62.2% were males, 75% were exclusively breastfed infants, 67.6% and 89.2% patients had ophthalmologic and respiratory abnormalities respectively. Multisystem involvement was common. Bilateral basal ganglia involvement was noted in 75% of neuroimaging. Biochemical thiamine deficiency was confirmed in one infant. None of the 11 patients who received thiamine died whereas 20 among 26 patients who did not receive thiamine died [case fatality rate (CFR) 76.9%]. Thiamine treatment was significantly associated with reduced odds of mortality (aOR 0.046, 95% CI 0.0024-0.86, p 0.039). In patients with acute non-infectious encephalopathy and bilateral basal ganglia involvement thiamine use was associated with decreased mortality.
(© 2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.)
Databáze: MEDLINE
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