Oral 5-aminolevulinic acid combined with sodium ferrous citrate prevents blood-aqueous barrier breakdown after anterior chamber paracentesis in healthy beagle dogs.

Autor: Otaka Y; Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan., Kanai K; Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan., Tomatsu A; Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan., Sangu R; Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan., Okada D; Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan., Nagai N; Faculty of Pharmacy, Kindai University, Osaka, Japan., Yamashita Y; Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan., Ichikawa Y; Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan., Sakai A; One Health Business Department, Companion Animal Group Neopharma Japan Co., Ltd., Tokyo, Japan., Tajima K; Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Jazyk: angličtina
Zdroj: The Journal of veterinary medical science [J Vet Med Sci] 2023 Dec 06; Vol. 85 (12), pp. 1257-1260. Date of Electronic Publication: 2023 Oct 24.
DOI: 10.1292/jvms.23-0347
Abstrakt: This study investigated the preventive effect of 5-aminolevulinic acid combined with sodium ferrous citrate (5-ALA/SFC) on blood-aqueous barrier (BAB) breakdown induced after anterior chamber paracentesis (ACP) in beagles. 5-ALA/SFC (1/0.64 mg/kg or 3/1.92 mg/kg) or carprofen (4.0 mg/kg) was orally administered daily for 7 days prior to ACP. Then, a sample of the aqueous humor (AH) was collected from one eye via ACP (first sample) and again 60 min later (second sample). The protein and prostaglandin E2 (PGE2) concentrations in both samples were measured. Compared with the control group, high-dose 5-ALA/SFC and carprofen significantly reduced the AH protein and PGE2 concentrations in the second sample. Our findings suggest that 5-ALA/SFC suppresses BAB breakdown in dogs.
Databáze: MEDLINE
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