Acute pancreatitis in Turkey: Results of a nationwide multicenter study.

Autor: Köksal AŞ; Sakarya University, School of Medicine, Department of Gastroenterology, Turkey. Electronic address: koksalas@yahoo.com., Tozlu M; Sakarya University, School of Medicine, Department of Gastroenterology, Turkey., Sezgin O; Mersin University, School of Medicine, Department of Gastroenterology, Turkey., Oğuz D; Kırıkkale University, School of Medicine, Department of Gastroenterology, Turkey., Kalkan İH; TOBB Economy and Technology University, Department of Gastroenterology, Turkey., Altıntaş E; Mersin University, School of Medicine, Department of Gastroenterology, Turkey., Yaraş S; Mersin University, School of Medicine, Department of Gastroenterology, Turkey., Bilgiç Y; İnönü University, School of Medicine, Department of Gastroenterology, Turkey., Yıldırım AE; Gaziantep University, School of Medicine, Department of Gastroenterology, Turkey., Barutçu S; Gaziantep University, School of Medicine, Department of Gastroenterology, Turkey., Hakim GD; Sağlık Bilimleri University, Izmir School of Medicine, Department of Gastroenterology, Turkey., Soytürk M; Dokuz Eylül University, School of Medicine, Department of Gastroenterology, Turkey., Bengi G; Dokuz Eylül University, School of Medicine, Department of Gastroenterology, Turkey., Özşeker B; Muğla Sıtkı Koçman University, School of Medicine, Department of Gastroenterology, Turkey., Yurci A; Erciyes University, School of Medicine, Department of Gastroenterology, Turkey., Koç DÖ; Sağlık Bilimleri University, Gaziosmanpaşa Education and Research Hospital, Department of Gastroenterology, Turkey., İrak K; Sağlık Bilimleri University, Başakşehir Çam and Sakura City Hospital, Department of Gastroenterology, Turkey., Kasap E; Manisa Celal Bayar University, School of Medicine, Department of Gastroenterology, Turkey., Cindoruk M; Ankara Gazi University, School of Medicine, Department of Gastroenterology, Turkey., Oruç N; Ege University, School of Medicine, Department of Gastroenterology, Turkey., Ünal NG; Ege University, School of Medicine, Department of Gastroenterology, Turkey., Şen İ; Sağlık Bilimleri University, Şişli Hamidiye Etfal Education and Research Hospital, Department of Gastroenterology, Turkey., Gökden Y; Sağlık Bilimleri University, Prof. Dr. Cemil Taşçıoğlu City Hosoital, Department of Gastroenterology, Turkey., Saruç M; Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Department of Gastroenterology, Turkey., Ünal H; Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Department of Gastroenterology, Turkey., Eminler AT; Sakarya University, School of Medicine, Department of Gastroenterology, Turkey., Toka B; Sakarya University, School of Medicine, Department of Gastroenterology, Turkey., Basır H; Mersin University, School of Medicine, Department of Gastroenterology, Turkey., Sağlam O; İnönü University, School of Medicine, Department of Gastroenterology, Turkey., Ergül B; Kırıkkale University, School of Medicine, Department of Gastroenterology, Turkey., Gül Ö; Kırıkkale University, School of Medicine, Department of Gastroenterology, Turkey., Büyüktorun İ; Dokuz Eylül University, School of Medicine, Department of Gastroenterology, Turkey., Özel M; Erciyes University, School of Medicine, Department of Gastroenterology, Turkey., Şair Ü; Sağlık Bilimleri University, Gaziosmanpaşa Education and Research Hospital, Department of Internal Medicine, Turkey., Kösem G; Manisa Celal Bayar University, School of Medicine, Department of Internal Medicine, Turkey., Nedirli F; Gazi University, School of Medicine, Department of Internal Medicine, Turkey., Tahtacı M; Ankara Yıldırım Beyazıt University, Department of Gastroenterology, Turkey., Parlak E; Hacettepe University, School of Medicine, Department of Gastroenterology, Turkey.
Jazyk: angličtina
Zdroj: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2024 May; Vol. 24 (3), pp. 327-334. Date of Electronic Publication: 2023 Oct 13.
DOI: 10.1016/j.pan.2023.10.005
Abstrakt: Background: Acute pancreatitis (AP) is the most common gastrointestinal disease requiring hospitalization, with significant mortality and morbidity. We aimed to evaluate the clinical characteristics of AP and physicians' compliance with international guidelines during its management.
Methods: All patients with AP who were hospitalized at 17 tertiary centers in Turkey between April and October 2022 were evaluated in a prospective cohort study. Patients with insufficient data, COVID-19 and those aged below 18 years were excluded. The definitions were based on the 2012 revised Atlanta criteria.
Results: The study included 2144 patients (median age:58, 52 % female). The most common etiologies were biliary (n = 1438, 67.1 %), idiopathic (n = 259, 12 %), hypertriglyceridemia (n = 128, 6 %) and alcohol (n = 90, 4.2 %). Disease severity was mild in 1567 (73.1 %), moderate in 521 (24.3 %), and severe in 58 (2.6 %) patients. Morphology was necrotizing in 4.7 % of the patients. The overall mortality rate was 1.6 %. PASS and BISAP had the highest accuracy in predicting severe pancreatitis on admission (AUC:0.85 and 0.81, respectively). CT was performed in 61 % of the patients, with the majority (90 %) being within 72 h after admission. Prophylactic NSAIDs were not administered in 44 % of the patients with post-ERCP pancreatitis (n = 86). Antibiotics were administered to 53.7 % of the patients, and 38 % of those received them prophylactically.
Conclusions: This prospective study provides an extensive report on clinical characteristics, management and outcomes of AP in real-world practice. Mortality remains high in severe cases and physicians' adherence to guidelines during management of the disease needs improvement in some aspects.
(Copyright © 2023 IAP and EPC. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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