Synovial sarcoma with ossification and calcification with SS18 immunochemical expression and rearrangement by fluorescent in situ hybridization.

Autor:	Acosta-Calderón LA; Department of Pathology, National Cancer Institute (Instituto Nacional de Cancerología), Mexico City, Mexico. Electronic address: Luisarturo4_0@hotmail.com., Lara-Torres C; Department of Pathology, National Cancer Institute (Instituto Nacional de Cancerología), Mexico City, Mexico., Lino-Silva LS; Department of Pathology, National Cancer Institute (Instituto Nacional de Cancerología), Mexico City, Mexico., Caro-Sánchez CH; Department of Pathology, National Cancer Institute (Instituto Nacional de Cancerología), Mexico City, Mexico., Jiménez-De Los Santos ME; Department of Radiodiagnosis, National Cancer Institute (Instituto Nacional de Cancerología), Mexico City, Mexico., Domínguez-Malagón HR; Department of Pathology, National Cancer Institute (Instituto Nacional de Cancerología), Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia [Rev Esp Patol] 2023 Oct-Dec; Vol. 56 (4), pp. 275-278. Date of Electronic Publication: 2023 Jul 01.
DOI:	10.1016/j.patol.2023.03.002
Abstrakt:	Synovial sarcoma is a soft tissue tumor of uncertain origin. Generally, it is a monophasic spindle cell neoplasm that can have glandular-like structures. Ossification and presence of calcification is a rare phenomenon with only a few reported cases. We present the case of a young male with a synovial sarcoma of the right foot. Histology revealed prominent deposits of tumoral osteoid and coarse calcifications. The diagnosis was confirmed by the expression of SS18 by immunohistochemistry and the demonstration of the rearrangement of the SS18 gene by fluorescent in situ hybridization. We reviewed the literature for synovial sarcoma with prominent ossification or calcification, and to the best of our knowledge, this is the first case with expression of SS18 by immunohistochemistry. The main differential diagnoses are osteosarcoma (both primary of bone and extraosseous) and sclerosing epithelioid fibrosarcoma. (Copyright © 2023 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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