Mixture effects of pharmaceuticals carbamazepine, diclofenac and venlafaxine on Mytilus galloprovincialis mussel probed by metabolomics and proteogenomics combined approach.

Autor: Dumas T; HydroSciences Montpellier, IRD, CNRS, University of Montpellier, Montpellier, France., Gomez E; HydroSciences Montpellier, IRD, CNRS, University of Montpellier, Montpellier, France., Boccard J; School of Pharmaceutical Sciences, University of Geneva, Geneva 1211, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva 1211, Switzerland., Ramirez G; HydroSciences Montpellier, IRD, CNRS, University of Montpellier, Montpellier, France., Armengaud J; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols-sur-Cèze, France., Escande A; HydroSciences Montpellier, IRD, CNRS, University of Montpellier, Montpellier, France., Mathieu O; HydroSciences Montpellier, IRD, CNRS, University of Montpellier, Montpellier, France; Laboratoire de Pharmacologie-Toxicologie, CHU de Montpellier, Montpellier, France., Fenet H; HydroSciences Montpellier, IRD, CNRS, University of Montpellier, Montpellier, France., Courant F; HydroSciences Montpellier, IRD, CNRS, University of Montpellier, Montpellier, France. Electronic address: frederique.courant@umontpellier.fr.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Jan 10; Vol. 907, pp. 168015. Date of Electronic Publication: 2023 Oct 23.
DOI: 10.1016/j.scitotenv.2023.168015
Abstrakt: Exposure to single molecules under laboratory conditions has led to a better understanding of the mechanisms of action (MeOAs) and effects of pharmaceutical active compounds (PhACs) on non-target organisms. However, not taking the co-occurrence of contaminants in the environment and their possible interactions into account may lead to underestimation of their impacts. In this study, we combined untargeted metabolomics and proteogenomics approaches to assess the mixture effects of diclofenac, carbamazepine and venlafaxine on marine mussels (Mytilus galloprovincialis). Our multi-omics approach and data fusion strategy highlighted how such xenobiotic cocktails induce important cellular changes that can be harmful to marine bivalves. This response is mainly characterized by energy metabolism disruption, fatty acid degradation, protein synthesis and degradation, and the induction of endoplasmic reticulum stress and oxidative stress. The known MeOAs and molecular signatures of PhACs were taken into consideration to gain insight into the mixture effects, thereby revealing a potential additive effect. Multi-omics approaches on mussels as sentinels offer a comprehensive overview of molecular and cellular responses triggered by exposure to contaminant mixtures, even at environmental concentrations.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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