Macroporous latex biomembrane from Hancornia speciosa modulates the inflammatory process and has a debridement effect on wound healing in rats.

Autor:	Martins KLE; Universidade Federal de Goiás - Tropical Pathology and Public Health Institute - Goiânia (GO) - Brazil., Thomaz MM; Instituto Master de Ensino Presidente Antônio Carlos - Medicine School - Itumbiara (GO) - Brazil., Magno LN; Universidade Federal de Goiás - Physics Institute - Goiânia (GO) - Brazil., Vinaud MC; Universidade Federal de Goiás - Tropical Pathology and Public Health Institute - Goiânia (GO) - Brazil., Almeida LM; Universidade Federal de Goiás - Anápolis (GO) - Brazil., Gonçalves PJ; Universidade Federal de Goiás - Physics Institute - Goiânia (GO) - Brazil., Lino Junior RS; Universidade Federal de Goiás - Physics Institute - Goiânia (GO) - Brazil.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2023 Oct 23; Vol. 38, pp. e385323. Date of Electronic Publication: 2023 Oct 23 (Print Publication: 2023).
DOI:	10.1590/acb385323
Abstrakt:	Purpose: The angiogenic, osteogenic and anti-inflammatory activity of latex of Hancornia speciosa has been evidenced and indicates pharmacological potential with great applicability in the health area, especially in the wound healing process. The present work aimed to compare the effects of the H. speciosa macroporous latex biomembrane with saline on wound healing. Methods: Forty-three Wistar rats were submitted to excisional wound induction procedure and divided into groups according to treatment: saline (G1), and macroporous biomembrane (G2). The animals were euthanized at three, seven, 14, and 21 days after injury induction (DAI), and three animals were used for the debridement test. Morphometric, macroscopic, and microscopic analyses of general pathological processes were performed. Results: The macroporous biomembrane minimized necrosis and inflammation during the inflammatory and proliferative phases of the healing process, confirmed by the lower intensity of the crust and the debridement effect. In addition, the wounds treated with the macroporous biomembrane presented greater contraction rates in all the experimental periods analyzed. Conclusions: The macroporous biomembrane presents angiogenic, anti-inflammatory and debridement effects, contributing to the healing process, and can be considered a potentially promising new biomaterial to be used as a dressing.
Databáze:	MEDLINE
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