Determining reference ranges for immunological cells of healthy indigenous individuals from a region in Brazil.

Autor: Morais IRB; Universidade Federal da Bahia , Salvador , BA , Brazil ., Barbosa DO; Universidade Federal da Bahia , Salvador , BA , Brazil ., Almeida GB; Universidade Federal da Bahia , Salvador , BA , Brazil ., Costa RRD; Universidade Federal da Grande Dourados , Dourados , MS , Brazil ., Silva BOD; Universidade Federal da Grande Dourados , Dourados , MS , Brazil ., Oliveira LA; Universidade Federal da Grande Dourados , Dourados , MS , Brazil ., Arantes JP; Universidade Federal da Grande Dourados , Dourados , MS , Brazil ., Leite LOC; Universidade Federal da Grande Dourados , Dourados , MS , Brazil ., Rossato L; Universidade Federal da Grande Dourados , Dourados , MS , Brazil ., Ribeiro MB; Universidade Federal da Bahia , Salvador , BA , Brazil ., Marchioro SB; Universidade Federal da Bahia , Salvador , BA , Brazil ., Freire SM; Universidade Federal da Bahia , Salvador , BA , Brazil ., Nascimento RJM; Universidade Federal da Bahia , Salvador , BA , Brazil ., Simionatto S; Universidade Federal da Bahia , Salvador , BA , Brazil ., Torres AJL; Universidade Federal da Bahia , Salvador , BA , Brazil .
Jazyk: angličtina
Zdroj: Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2023 Oct 23; Vol. 21, pp. eAO0291. Date of Electronic Publication: 2023 Oct 23 (Print Publication: 2023).
DOI: 10.31744/einstein_journal/2023AO0291
Abstrakt: Morais et al. conducted a pioneering study with Brazilian indigenous populations to determine reference values for immunologic cells from healthy adult individuals. The main findings included a higher relative median for T lymphocyte subsets in females than males, and T CD3+, T CD4+, and T CD8+ relative values were statistically different when compared with Brazilian populations from other Brazilian regions. The relative medians of CD3+, CD4+, and CD8+ T cells were significantly higher in women than in men in a healthy indigenous population. Demographic and ethnic diversity of the Brazilian population can be associated with quantitative modifications in the immunologic cells of healthy individuals.
Objective: The establishment of reference values for a subset of leukocytes is common in clinical practice, and ethnic variations are strongly associated with disease development. In Brazil, indigenous people are vulnerable to infections, and few studies have described the health and disease conditions of this population. This study aimed to provide reference values for immunological cell subsets in indigenous Brazilians living in the state of Mato Grosso do Sul.
Methods: Flow cytometry and 4-color combinations of monoclonal antibodies were used to characterize cells. A total of 115 healthy adults, mostly females (72%), were included in the study. The results are presented as mean and median (2.5%-97.5% percentiles) for T and B lymphocytes, CD4+ T cells, CD8+ T cells, Natural Killer cells, monocytes, and dendritic cells, providing an average immunological profile for the population in question.
Results: The relative medians of CD3+, CD4+, and CD8+ T cells were significantly higher in women than in men in a healthy indigenous population.
Conclusion: To our knowledge, cell reference data from indigenous Brazilians are unknown in the literature. The immune cell results presented in this pioneering study will contribute to the clinical and laboratory evaluation of the Brazilian indigenous population, especially given the important differences when compared with other Brazilian ethnic groups.
Databáze: MEDLINE
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