| Autor: |
Kopcha WP; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd., Piscataway, NJ, 08854, USA. jy.zhang@rutgers.edu., Biswas R; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd., Piscataway, NJ, 08854, USA. jy.zhang@rutgers.edu., Sun Y; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd., Piscataway, NJ, 08854, USA. jy.zhang@rutgers.edu., Chueng SD; Vitale Biotechnology, Inc., 700 West Park Ave., Perkasie, PA, 18944, USA., Dorn HC; Department of Chemistry, Virginia Polytechnic Institute and State University, 1040 Drillfield Dr, Blacksburg, VA, 24061, USA. hdorn@vt.edu., Zhang J; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Rd., Piscataway, NJ, 08854, USA. jy.zhang@rutgers.edu. |
| Abstrakt: |
Endohedral metallofullerenes (EMFs) offer a safe avenue to manipulate metals important to biomedical applications such as MRI contrast, X-ray contrast, radiolabeling, radiotherapy, chemotherapy, and the control of inflammation by scavenging reactive oxygen species (ROS). Moreover, functionalizing the double bonds on the surface of EMFs modifies their solubility, supramolecular behaviour, binding, targeting characteristics, and physical properties. While most existing water-soluble derivatives possess a statistical mixture of appended functional groups, progress has been made in creating molecularly-precise derivatives with a defined number of surface functional groups, leading to potentially more nuanced control of their behaviour and properties. Further elucidation of the structure-function relationships of these materials is expected to enhance their utility in biomedical applications and possibly broaden their use in diverse areas of science and technology. |
