Survival Outcome in True Carcinoma of Unknown Primary (tCUP) with p16 + Cervical Metastasis.

Autor: Faisal M; Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.; Institute of Head and Neck Diseases, Evangelical Hospital, Vienna, Austria., Le NS; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria., Grasl S; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria., Pammer J; Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria., Janik S; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria., Heiduschka G; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria., Schratter-Sehn AU; Institute of Radio-Oncology, Kaiser-Franz-Josef Hospital, Vienna, Austria., Franz P; Department of Otorhinolaryngology, Head and Neck Surgery, Rudolfstiftung Hospital, Vienna, Austria., Königswieser M; Department of Otorhinolaryngology, Head and Neck Surgery, Rudolfstiftung Hospital, Vienna, Austria., Grasl MC; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria., Erovic BM; Institute of Head and Neck Diseases, Evangelical Hospital, Vienna, Austria.
Jazyk: angličtina
Zdroj: International archives of otorhinolaryngology [Int Arch Otorhinolaryngol] 2023 Oct 23; Vol. 27 (4), pp. e687-e693. Date of Electronic Publication: 2023 Oct 23 (Print Publication: 2023).
DOI: 10.1055/s-0042-1759575
Abstrakt: Introduction  Age and lymph node ratio have been attributed as independent predictors for survival and recurrence in carcinoma of unknown primary (CUP). Objective  The purpose of this study was to analyze the prognostic value of p16 overexpression for CUP in the absence of true primary (TP). Methods  The study involved 43 patients who underwent therapeutic lymph node dissection (LND) from 2000 to 2015 after all the diagnostic work up for CUP. Immunohistochemistry for p16 overexpression was performed. Cox proportional hazard regression analysis was used to analyze the prognostic impact on 5-year overall survival (OS) and recurrence-free survival (RFS). Results  The male-to-female ratio was 5.1:1, with a median age of 62 years. The clinicopathological data, except for p16 overexpression, did not differ significantly in terms of 5-year OS and RFS. The Cox regression analysis proposed p16 positivity to be an independent prognosticator of regional recurrence-free survival (RRFS) (hazard ratio [HR] 6.180, p  = 0.21). The median time to recurrence and death were 10 and 25 months, respectively. Conclusion  Cervical metastasis with p16 overexpression is a significant prognostic factor of improved RFS after surgery in CUP. The prognostic significance of lymph node p16 positivity should be further studied.
Competing Interests: Conflict of Interests The authors have no conflict of interests to declare.
(Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
Databáze: MEDLINE
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