Severe intestinal barrier damage in HIV-infected immunological non-responders.

Autor:	Guo XY; Beijing Ditan Hospital, Capital Medical University, Beijing, China.; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Guo YT; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China., Wang ZR; Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital, Beijing, China., Jiao YM; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Hu Y; Department of Infectious Diseases, Tianjin Second People's Hospital, Tianjin, China., Fan LN; Department of Infectious Diseases, Tianjin Second People's Hospital, Tianjin, China., Cheng RQ; Tianjin Bright Eye Hospital, Tianjin, China., Qu MM; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Zhang C; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Song JW; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Xu RN; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Fan X; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Xu W; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Zhang JY; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Bai BK; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China., Linghu EQ; Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital, Beijing, China., Chen YK; Department of Infectious Disease, Chongqing Public Health Medical Center, Chongqing, China., Ma P; Department of Infectious Diseases, Tianjin Second People's Hospital, Tianjin, China., Wang FS; Beijing Ditan Hospital, Capital Medical University, Beijing, China.; Senior Department of Infectious Diseases, the Fifth Medical Centre of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Oct 12; Vol. 9 (10), pp. e20790. Date of Electronic Publication: 2023 Oct 12 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e20790
Abstrakt:	The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological responders (IRs) is largely unknown. In this study, we investigated and compared the levels of intestinal gland damage and related molecules, including the tight junction protein claudin-1, apoptosis marker caspase-3, HIV DNA, CD4 + T cell count, and inflammation marker tumor necrosis factor-α (TNF-α) among the IRs (n = 10), INRs (n = 8), and healthy controls (HCs, n = 7). Intestinal damage was not completely restored in both INRs and IRs and was more serious in INRs than that in IRs. Moreover, intestinal damage was positively correlated with HIV DNA levels and negatively correlated with CD4 + T cell counts. These results provide insight into understanding the characteristics of intestinal epithelial barrier damage between IRs and INRs. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 Published by Elsevier Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu