Progressive Multifocal Leukoencephalopathy Presenting as Primary CNS Malignancy in an Immunocompetent Patient.
| Autor: | Truong RD; Department of Internal Medicine, Orlando Regional Medical Center, Orlando, USA., Vadlapatla VK; Department of Hematology and Medical Oncology, Orlando Regional Medical Center, Orlando, USA., Avgeropoulos NG; Department of Hematology and Medical Oncology, Orlando Regional Medical Center, Orlando, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Sep 23; Vol. 15 (9), pp. e45815. Date of Electronic Publication: 2023 Sep 23 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.45815 |
| Abstrakt: | Progressive multifocal leukoencephalopathy (PML) is an infection caused by the John Cunningham virus (JCV), usually in an immunocompromised host. We present the case of a 74-year-old male who presented with a six-week history of progressive memory loss, episodic confusion, and aphasia. Cranial nerve, motor, sensory, and coordination testing were unremarkable. Magnetic resonance imaging (MRI) of the brain and spectroscopy were concerning for primary CNS lymphoma vs. diffuse glioma. Microscopic examination after the patient underwent left frontal stereotactic brain biopsy was suggestive of a viral infection, and further testing with JCV DNA in-situ hybridization (ISH) confirmed the diagnosis of PML. The patient's condition started resolving without treatment. This case demonstrates, to our knowledge, the first known case of primary PML masquerading as CNS lymphoma in modern literature. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Truong et al.) |
| Databáze: | MEDLINE |
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