Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period.

Autor: Peter HL; Institute of Psychology, University of Regensburg, Regensburg, Germany., Giglberger M; Institute of Psychology, University of Regensburg, Regensburg, Germany., Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, Mannheim, Germany., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, Mannheim, Germany., Kreuzpointner L; Institute of Psychology, University of Regensburg, Regensburg, Germany., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Mannheim, Mannheim, Germany., Kudielka BM; Institute of Psychology, University of Regensburg, Regensburg, Germany., Wüst S; Institute of Psychology, University of Regensburg, Regensburg, Germany.
Jazyk: angličtina
Zdroj: Genes, brain, and behavior [Genes Brain Behav] 2023 Dec; Vol. 22 (6), pp. e12872. Date of Electronic Publication: 2023 Oct 24.
DOI: 10.1111/gbb.12872
Abstrakt: Genetic factors contribute significantly to interindividual differences in the susceptibility to stress-related disorders. As stress can also be conceptualized as environmental exposure, controlled gene-environment interaction (GxE) studies with an in-depth phenotyping may help to unravel mechanisms underlying the interplay between genetic factors and stress. In a prospective-longitudinal quasi-experimental study, we investigated whether polygenic scores (PGS) for depression (DEP-PGS) and neuroticism (NEU-PGS), respectively, were associated with responses to chronic stress in daily life. We examined law students (n = 432) over 13 months. Participants in the stress group experienced a long-lasting stress phase, namely the preparation for the first state examination for law students. The control group consisted of law students without particular stress exposure. In the present manuscript, we analyzed perceived stress levels assessed at high frequency and in an ecologically valid manner by ambulatory assessments as well as depression symptoms and two parameters of the cortisol awakening response. The latter was only assessed in a subsample (n = 196). No associations between the DEP-PGS and stress-related variables were found. However, for the NEU-PGS we found a significant GxE effect. Only in individuals experiencing academic stress a higher PGS for neuroticism predicted stronger increases of perceived stress levels until the exam. At baseline, a higher NEU-PGS was associated with higher perceived stress levels in both groups. Despite the small sample size, we provide preliminary evidence that the genetic disposition for neuroticism is associated with stress level increases in daily life during a long-lasting stress period.
(© 2023 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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