A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study.

Autor: Tor-Roca A; Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain., Sánchez-Pla A; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain., Korosi A; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, 1098 XH, The Netherlands., Pallàs M; Pharmacology Section, Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institut of Neurosciences, University of Barcelona, Barcelona, 08028, Spain.; Centro de Investigación Biomédica en Red en Neurodegeneracion, Instituto de Salud Carlos III, Madrid, 28029, Spain., Lucassen PJ; Brain Plasticity Group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, 1098 XH, The Netherlands., Castellano-Escuder P; Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain., Aigner L; Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, 5020, Austria., González-Domínguez R; Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain., Manach C; Université Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, F-63000, France., Carmona F; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain., Vegas E; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain., Helmer C; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France., Feart C; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France., Lefèvre-Arbogast S; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France., Neuffer J; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France., Lee H; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Thuret S; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Andres-Lacueva C; Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain., Samieri C; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, F-33000, France., Urpi-Sarda M; Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Food Science and Nutrition Torribera Campus, University of Barcelona, Santa Coloma de Gramenet, 08921, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, 28029, Spain.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2024 Jul; Vol. 68 (13), pp. e2300271. Date of Electronic Publication: 2023 Oct 24.
DOI: 10.1002/mnfr.202300271
Abstrakt: Scope: Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older adults.
Methods and Results: This study includes participants from the Three-City Study from the Bordeaux (n = 418) and Dijon (n = 422) cohorts who are free of dementia at baseline. Repeated measures of cognition over 12 years are collected. An MDMS is designed based on serum biomarkers related to MD key food groups and using a targeted metabolomics platform. Associations with CD are investigated through conditional logistic regression (matched on age, sex, and education level) in both sample sets. The MDMS is found to be inversely associated with CD (odds ratio [OR] [95% confidence interval (CI)] = 0.90 [0.80-1.00]; p = 0.048) in the Bordeaux (discovery) cohort. Results are comparable in the Dijon (validation) cohort, with a trend toward significance (OR [95% CI] = 0.91 [0.83-1.01]; p = 0.084).
Conclusions: A greater adherence to the MD, here assessed by a serum MDMS, is associated with lower odds of CD in older adults.
(© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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