The spatiotemporal dynamics of semantic integration in the human brain.

Autor: Murphy E; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. elliot.murphy@uth.tmc.edu.; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. elliot.murphy@uth.tmc.edu., Forseth KJ; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Donos C; Faculty of Physics, University of Bucharest, Măgurele, 077125, Bucharest, Romania., Snyder KM; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Rollo PS; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Tandon N; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. nitin.tandon@uth.tmc.edu.; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. nitin.tandon@uth.tmc.edu.; Memorial Hermann Hospital, Texas Medical Center, Houston, TX, 77030, USA. nitin.tandon@uth.tmc.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Oct 24; Vol. 14 (1), pp. 6336. Date of Electronic Publication: 2023 Oct 24.
DOI: 10.1038/s41467-023-42087-8
Abstrakt: Language depends critically on the integration of lexical information across multiple words to derive semantic concepts. Limitations of spatiotemporal resolution have previously rendered it difficult to isolate processes involved in semantic integration. We utilized intracranial recordings in epilepsy patients (n = 58) who read written word definitions. Descriptions were either referential or non-referential to a common object. Semantically referential sentences enabled high frequency broadband gamma activation (70-150 Hz) of the inferior frontal sulcus (IFS), medial parietal cortex, orbitofrontal cortex (OFC) and medial temporal lobe in the left, language-dominant hemisphere. IFS, OFC and posterior middle temporal gyrus activity was modulated by the semantic coherence of non-referential sentences, exposing semantic effects that were independent of task-based referential status. Components of this network, alongside posterior superior temporal sulcus, were engaged for referential sentences that did not clearly reduce the lexical search space by the final word. These results indicate the existence of complementary cortical mosaics for semantic integration in posterior temporal and inferior frontal cortex.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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