Physical compatibility of lipid emulsions and intravenous medications used in neonatal intensive care settings.

Autor:	Senarathna SMDKG; Curtin Medical School, Curtin University, Perth, Western Australia, Australia., Strunk T; Medical School, University of Western Australia, Crawley, Western Australia, Australia.; Neonatal Directorate, Child and Adolescent Health Service, Subiaco, Western Australia, Australia., Petrovski M; Pharmacy Department, Women and Newborn Health Service, Subiaco, Western Australia, Australia., Woodland S; Pharmacy Department, Women and Newborn Health Service, Subiaco, Western Australia, Australia., Martinez J; Curtin Medical School, Curtin University, Perth, Western Australia, Australia., Chuang VTG; Curtin Medical School, Curtin University, Perth, Western Australia, Australia., Batty KT; Curtin Medical School, Curtin University, Perth, Western Australia, Australia kevin.batty@curtin.edu.au.; Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
Jazyk:	angličtina
Zdroj:	European journal of hospital pharmacy : science and practice [Eur J Hosp Pharm] 2023 Oct 23. Date of Electronic Publication: 2023 Oct 23.
DOI:	10.1136/ejhpharm-2023-003870
Abstrakt:	Objective: The purpose of this study was to investigate the physical compatibility of intravenous lipid emulsions with parenteral medications used in neonatal intensive care. Methods: Lipid emulsion and drug solutions were combined 1:1 in glass vials, inspected for physical incompatibility at 0, 1 and 2 hours, and assessed on the basis of lipid droplet size at 0 and 2 hours after mixing. Intravenous fluid controls (Water for Injection, sodium chloride 0.9% w/v, glucose 5% w/v), positive controls (gentamicin, albumin), negative controls (metronidazole, paracetamol, vancomycin) and 21 previously untested drug combinations were evaluated. Results: No phase separation, change in colour, gas production or other visible anomaly was observed. The between-run mean droplet diameter (MDD) for SMOFlipid20% alone (0.301±0.008 µm) was comparable to the lipid emulsion/intravenous fluid and lipid emulsion/drug solution combinations. In addition to gentamicin and albumin, caffeine citrate (20 mg/mL) was shown to be incompatible with the lipid emulsion. All other lipid:drug combinations were compatible, based on the MDD data. Conclusion: Intravenous lipid emulsions were found to be compatible with 20 parenteral medications, including antimicrobial agents, inotropes, anti-inflammatory drugs and caffeine base, in simulated Y-site conditions. The lipid emulsion was incompatible with caffeine citrate injection. Competing Interests: Competing interests: None declared. (© European Association of Hospital Pharmacists 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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