Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy improves lipid and glucose homeostasis in ob/ob mice.

Autor: Frey S; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France.; Nantes Université, CHU Nantes, Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Nantes, France., Ayer A; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France., Sotin T; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France., Lorant V; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France., Louis-Gaubert C; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France.; Nantes Université, CHU Nantes, Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Nantes, France., Arnaud L; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France., Billon-Crossouard S; Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.; CRNH-Ouest Mass Spectrometry Core Facility, Nantes, France., Croyal M; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France.; Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.; CRNH-Ouest Mass Spectrometry Core Facility, Nantes, France., Prieur X; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France., Hadjadj S; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France., Cariou B; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France., Blanchard C; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France.; Nantes Université, CHU Nantes, Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Nantes, France., Le May C; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du thorax, Nantes, France.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 Jan; Vol. 32 (1), pp. 91-106. Date of Electronic Publication: 2023 Oct 24.
DOI: 10.1002/oby.23916
Abstrakt: Objective: The objective of this study was to compare the general and metabolic impact of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) with Roux-en-Y gastric bypass (RYGB) in an obese (ob/ob) mouse model.
Methods: 10-week-old male ob/ob mice underwent either SADI-S, RYGB, or laparotomy surgery (Sham group). General and metabolic parameters were assessed during a 5-week period thereafter.
Results: SADI-S induced a deeper weight loss ([mean ± SEM] -41.2% ± 3.3%) than RYGB (-5.6% ± 3.5%, p < 0.001) compared with the Sham group (+6.3% ± 1.0%, p < 0.05). A significant food restriction was observed after SADI-S only (-31%, 117.4 ± 10.3 g vs. 170.2 ± 5.2 g of food at day 35 in Sham group mice, p < 0.001). Random-fed glycemia and glucose tolerance were more improved after SADI-S than RYGB. SADI-S decreased plasma cholesterol concentration by 60% (0.49 ± 0.04 g/L vs. 1.40 ± 0.10 g/L in the Sham group at day 35, p < 0.01), significantly more than RYGB (1.04 ± 0.14 g/L, p = 0.018). Plasma sitosterol/cholesterol and campesterol/cholesterol ratios were decreased after SADI-S, suggesting a reduced intestinal cholesterol absorption. SADI-S increased exogenous plasma cholesterol-D7 clearance and fecal elimination, also indicating an increased plasma cholesterol excretion. Studying a pair-fed group demonstrated that calorie restriction alone did not explain the beneficial impact of SADI-S.
Conclusions: SADI-S is associated with a greater improvement in lipid and glucose homeostasis than RYGB in ob/ob mice.
(© 2023 The Obesity Society.)
Databáze: MEDLINE
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