Serum reactivity to citrullinated protein/peptide antigens and left ventricular structure and function in the Multi-Ethnic Study of Atherosclerosis (MESA).

Autor: Hughes-Austin JM; Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, California, United States of America., Katz R; Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, United States of America., Majka DS; Division of Rheumatology, DuPage Medical Group, Chicago, Illinois, United States of America., Criqui MH; Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California, United States of America., Robinson WH; Division of Immunology and Rheumatology, Stanford University, Stanford, California, United States of America.; VA Palo Alto Health Care System, Palo Alto, California, United States of America., Firestein GS; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, University of California, San Diego, La Jolla, California, United States of America., Hundley WG; Virginia Commonwealth University, Richmond, Virginia, United States of America., Ix JH; Division of Nephrology-Hypertension, Department of Medicine, University of California, San Diego, La Jolla, California, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Oct 24; Vol. 18 (10), pp. e0291967. Date of Electronic Publication: 2023 Oct 24 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0291967
Abstrakt: Background: Antibodies to citrullinated protein antigens have been linked to altered left ventricular (LV) structure and function in patients with rheumatoid arthritis (RA). Serum reactivity to several citrullinated protein/peptide antigens has been identified in RA, which are detectable years before RA onset and in individuals who may never develop RA. Among community-living individuals without heart failure (HF) at baseline in the Multi-Ethnic Study of Atherosclerosis (MESA), we investigated associations between serum reactivity to citrullinated protein/peptide antigens, LV mass, LV ejection fraction (LVEF), and incident HF.
Methods: Among 1232 MESA participants, we measured serum reactivity to 28 different citrullinated proteins/peptides using a multiplex bead-based array. Each antibody was defined as having extremely high reactivity (EHR) if >95th percentile cut-off in MESA. Number of EHR antibody responses to citrullinated protein/peptide antigens were summed for each participant (range 0-28). LV mass(g) and LVEF(%) were measured on cardiac MRI. Associations between EHR antibodies and LV mass and LVEF were evaluated using linear regression. Cox proportional hazards models were used to evaluate associations between EHR antibodies and incident HF during 11 years of follow-up, adjusting for age, gender, race/ethnicity, smoking status, systolic blood pressure, use of anti-hypertensive medications, self-reported arthritis, IL-6, body surface area, and estimated glomerular filtration rate.
Results: Mean age was 65±10, 50% were female, 40% were White, 21% were Black, 26% were Hispanic/Latino, and 14% were Chinese. Twenty-seven percent of MESA participants had extremely high reactivity to ≥ 1 citrullinated protein/peptide antigen. In fully adjusted analysis, every additional EHR antibody was significantly associated with 0.1% lower LVEF (95% CI: -0.17%, -0.02%). No association was observed with LV mass (β per additional EHR antibody) = 0.13±0.15 (p = 0.37)). Neither the presence nor number of EHR antibodies was associated with incident HF during follow-up (HR per additional EHR antibody = 1.008 (95% CI: 0.97, 1.05)).
Conclusion: Greater number of extremely highly reactive antibodies was associated with lower LVEF, but not with LV mass or incident HF. Thus, serum reactivity to citrullinated protein/peptide antigens was associated with subtle subclinical changes in myocardial contractility, but the significance in relation to clinically apparent HF is uncertain.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Hughes-Austin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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