Changes in leukocyte telomere length among children with obesity participating in a behavioural weight control program.

Autor: Rehkopf DH; Departments of Epidemiology and Population Health, Medicine, Pediatrics and Sociology, Stanford University, Stanford, California, USA., Wojcicki JM; Departments of Pediatrics and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA., Haydel KF; Department of Pediatrics, Stanford University, Stanford, California, USA., Lin J; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA., Smith DL; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA., Kapphahn KI; Quantitative Sciences Unit, Stanford University, Stanford, California, USA., Robinson TN; Departments of Pediatrics and Medicine and by courtesy Epidemiology and Population Health, Stanford University, Stanford, California, USA.
Jazyk: angličtina
Zdroj: Pediatric obesity [Pediatr Obes] 2023 Dec; Vol. 18 (12), pp. e13082. Date of Electronic Publication: 2023 Oct 24.
DOI: 10.1111/ijpo.13082
Abstrakt: Objective: To examine changes in leukocyte telomere length (LTL) during and after a behavioural weight control program for children with obesity.
Methods: We measured LTL among a cohort of 158 children 8-12 years of age with a body mass index greater than or equal to the 95th percentile for age and sex. Children were 55% female, 29% white, 52% Latinx, 8% Asian and 11% Pacific Islander, other or multiethnic. All children participated in a 6-month, family-based, group behavioural weight control program and were assessed before treatment, after treatment and 1 year after the end of treatment. To test the sample population slope of LTL over the intervention and maintenance time periods, we fit spline mixed-effect regression models.
Results: LTL increased an average of 0.09 T/S units per year (95% confidence interval [CI] 0.04 to 0.13; p = 0.0001) during the weight control program intervention period, followed by an average decline of -0.05 T/S units per year (95% CI -0.08 to -0.03; p < 0.0001) during the 1 year of follow-up after the completion of the intervention. Among 26 social, psychological, behavioural and physiological factors we examined, we did not find any predictors of these changes.
Conclusions: LTL increased in response to a behavioural weight control program among children with obesity, suggesting an impact on biological health and cellular aging from participation in a behavioural weight control intervention. LTL may be a useful biomarker for assessing changes in response to behavioural interventions.
(© 2023 World Obesity Federation.)
Databáze: MEDLINE
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