| Autor: |
Tang H; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA., Rybski KJ; Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA., Luan Y; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06510, USA., Smoller BR; Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Dermatopathology (Basel, Switzerland) [Dermatopathology (Basel)] 2023 Oct 23; Vol. 10 (4), pp. 303-309. Date of Electronic Publication: 2023 Oct 23. |
| DOI: |
10.3390/dermatopathology10040038 |
| Abstrakt: |
Programmed cell death protein 1 (PD-1) plays a pivotal role in immune system regulation, with its expression levels linked to malignancy prognosis. However, existing reports on PD-1 staining in mycosis fungoides (MF) present conflicting findings, and little attention has been given to PD-1 staining in different MF variants. To address this, we conducted a retrospective study, employing immunohistochemistry to examine PD-1 expression in cases of folliculotropic MF and non-folliculotropic MF. We analyzed 24 cases of folliculotropic MF and 18 cases of non-folliculotropic MF, and recorded both the percentage of PD-1-labeled tumor cells and the intensity score (negative, weak, medium, or strong). Our results revealed significant disparity in PD-1 labeling between patch/plaque MF and folliculotropic MF ( p = 0.028). Non-folliculotropic MF exhibited higher PD-1 labeling in tumor cells (58.3%) compared to folliculotropic MF (40.2%). Notably, there was no significant difference in PD-1 staining between folliculotropic MF and non-folliculotropic MF when both were in the early stage/indolent disease category. However, when considering the tumor stage, folliculotropic MF exhibited PD-1 staining in tumor cells at a rate of 21.1%, while non-folliculotropic MF showed PD-1 staining in tumor cells at a rate of 46.6% ( p = 0.005). Additionally, among folliculotropic MF cases, 13 out of 24 cases displayed differing PD-1 expression patterns between epidermal and dermal components, with preserved PD-1 staining in the epidermal component and loss of staining in the dermal component. Furthermore, consistent with the prior literature, tumor cells with large cell transformations exhibited significantly lower PD-1 labeling ( p = 0.017). Our findings showcase the unique PD-1 staining patterns in MF. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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