Haplosufficiency of MHCII in autoreactive germinal center B cells.

Autor: Fahlquist-Hagert C; Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Wittenborn TR; Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Ferapontov A; Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Jensen L; Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Terczyńska-Dyla E; Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Degn SE; Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Jazyk: angličtina
Zdroj: European journal of immunology [Eur J Immunol] 2024 Jan; Vol. 54 (1), pp. e2350422. Date of Electronic Publication: 2023 Nov 09.
DOI: 10.1002/eji.202350422
Abstrakt: Utilizing an autoimmune bone marrow chimera model we determined that B cells depend critically on MHCII expression for participation in the germinal center, but cells displaying a 50% reduction in surface MHCII compete efficiently with their wild-type counterparts. This provides insights into the requirements for germinal center participation.
(© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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