Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia.

Autor:	Jiang Y; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., Luo C; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.; High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China.; Research Unit of NeuroInformation (2019RU035), Chinese Academy of Medical Sciences, Chengdu, China., Wang J; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Palaniyappan L; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Canada., Chang X; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., Xiang S; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., Zhang J; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., Duan M; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China., Huang H; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China., Gaser C; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.; Department of Neurology, Jena University Hospital, Jena, Germany.; German Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Germany., Nemoto K; Department of Psychiatry, Division of Clinical Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, 305-8575, Japan., Miura K; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, 187-8553, Japan., Hashimoto R; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, 187-8553, Japan., Westlye LT; Department of Psychology, University of Oslo, Oslo, Norway.; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway., Richard G; Department of Psychology, University of Oslo, Oslo, Norway.; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway., Fernandez-Cabello S; Department of Psychology, University of Oslo, Oslo, Norway.; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway., Parker N; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Andreassen OA; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Kircher T; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany., Nenadić I; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany., Stein F; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany., Thomas-Odenthal F; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany., Teutenberg L; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany., Usemann P; Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Grotegerd D; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Lencer R; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry and Psychotherapie and Center for Brain, Behavior and Metabolism, Lübeck University, Lübeck, Germany.; Institute for Transnational Psychiatry and Otto Creutzfeldt Center for Behavioral and Cognitive Neuroscience, University of Münster, Münster, Germany., Tang Y; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang T; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li C; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Yue W; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China.; Chinese Institute for Brain Research, Beijing, PR China.; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, PR China., Zhang Y; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China., Yu X; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China., Zhou E; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China., Lin CP; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tsai SJ; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan., Rodrigue AL; Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston MA, USA., Glahn D; Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston MA, USA., Pearlson G; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley, Brownsville, TX, USA., Karuk A; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Spain., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Spain., Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Spain., Fuentes-Claramonte P; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Spain., Garcia-León MÁ; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Spain., Spalletta G; Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy., Piras F; Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy., Vecchio D; Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy., Banaj N; Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy., Cheng J; Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Liu Z; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Yang J; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Gonul AS; Ege University School of Medicine Department of Psychiatry, SoCAT Lab, Izmir, Turkey., Uslu O; Ege University Institute of Health Sciences Department of Neuroscience, Izmir, Turkey., Burhanoglu BB; Ege University Institute of Health Sciences Department of Neuroscience, Izmir, Turkey., Demir AU; Ege University School of Medicine Department of Psychiatry, SoCAT Lab, Izmir, Turkey., Rootes-Murdy K; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology, Emory University], Atlanta, GA, USA., Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology, Emory University], Atlanta, GA, USA., Sim K; West Region, Institute of Mental Health, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Green M; School of Clinical Medicine, University of New South Wales, Sydney, Australia., Quidé Y; School of Psychology, University of New South Wales, Sydney, Australia., Chung YC; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.; Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea., Kim WS; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea., Sponheim SR; Minneapolis VA Medical Center, University of Minnesota, Minneapolis, MN, USA.; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Demro C; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA., Ramsay IS; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA., Iasevoli F; Section of Psychiatry - Department of Neuroscience - University 'Federico II', Naples, Italy., de Bartolomeis A; Section of Psychiatry - Department of Neuroscience - University 'Federico II', Naples, Italy., Barone A; Section of Psychiatry - Department of Neuroscience - University 'Federico II', Naples, Italy., Ciccarelli M; Section of Psychiatry - Department of Neuroscience - University 'Federico II', Naples, Italy., Brunetti A; Department of Advanced Biomedical Sciences - University 'Federico II', Naples, Italy., Cocozza S; Department of Advanced Biomedical Sciences - University 'Federico II', Naples, Italy., Pontillo G; Department of Advanced Biomedical Sciences - University 'Federico II', Naples, Italy., Tranfa M; Department of Advanced Biomedical Sciences - University 'Federico II', Naples, Italy., Park MTM; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.; Centre for Addiction and Mental Health, Toronto, Canada., Kirschner M; Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, Switzerland.; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich, Switzerland., Georgiadis F; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich, Switzerland., Kaiser S; Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, Switzerland., Rheenen TEV; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia.; Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, Melbourne, Australia., Rossell SL; Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, Melbourne, Australia., Hughes M; Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, Melbourne, Australia., Woods W; Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, Melbourne, Australia., Carruthers SP; Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, Melbourne, Australia., Sumner P; Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, Melbourne, Australia., Ringin E; National Institute of Mental Health, Klecany, Czech Republic., Spaniel F; National Institute of Mental Health, Klecany, Czech Republic., Skoch A; National Institute of Mental Health, Klecany, Czech Republic.; MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic., Tomecek D; National Institute of Mental Health, Klecany, Czech Republic.; Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic., Homan P; Psychiatric Hospital, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich & Swiss Federal Institute of Technology Zurich, Zurich, Switzerland., Homan S; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, Switzerland.; Experimental Psychopathology and Psychotherapy, Department of Psychology, University of Zurich, Switzerland., Omlor W; Psychiatric Hospital, University of Zurich, Zurich, Switzerland., Cecere G; Psychiatric Hospital, University of Zurich, Zurich, Switzerland., Nguyen DD; Department of Pediatrics, University of California Irvine, Irvine, California, USA., Preda A; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, USA., Thomopoulos S; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Jahanshad N; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Cui LB; Department of Clinical Psychology, Fourth Military Medical University, Xi'an, PR China., Yao D; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.; High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China.; Research Unit of NeuroInformation (2019RU035), Chinese Academy of Medical Sciences, Chengdu, China., Thompson PM; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Turner JA; Psychiatry and Behavioral Health, Ohio State Wexner Medical Center, Columbus, OH, USA., van Erp TGM; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine Hall, room 109, Irvine, CA, 92697-3950, USA.; Center for the Neurobiology of Learning and Memory, University of California Irvine, 309 Qureshey Research Lab, Irvine, CA, 92697, USA., Cheng W; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.; Shanghai Medical College and Zhongshan Hospital Immunotherapy Technology Transfer Center, Shanghai, China.; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.; Fudan ISTBI-ZJNU Algorithm Centre for Brain-Inspired Intelligence, Zhejiang Normal University, Jinhua, China., Feng J; Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.; Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.; Fudan ISTBI-ZJNU Algorithm Centre for Brain-Inspired Intelligence, Zhejiang Normal University, Jinhua, China.; MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.; Zhangjiang Fudan International Innovation Center, Shanghai, China.; School of Data Science, Fudan University, Shanghai, China.; Department of Computer Science, University of Warwick, Coventry CV4 7AL, UK.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2023 Oct 12. Date of Electronic Publication: 2023 Oct 12.
DOI:	10.1101/2023.10.11.23296862
Abstrakt:	Machine learning can be used to define subtypes of psychiatric conditions based on shared clinical and biological foundations, presenting a crucial step toward establishing biologically based subtypes of mental disorders. With the goal of identifying subtypes of disease progression in schizophrenia, here we analyzed cross-sectional brain structural magnetic resonance imaging (MRI) data from 4,291 individuals with schizophrenia (1,709 females, age=32.5 years±11.9) and 7,078 healthy controls (3,461 females, age=33.0 years±12.7) pooled across 41 international cohorts from the ENIGMA Schizophrenia Working Group, non-ENIGMA cohorts and public datasets. Using a machine learning approach known as Subtype and Stage Inference (SuStaIn), we implemented a brain imaging-driven classification that identifies two distinct neurostructural subgroups by mapping the spatial and temporal trajectory of gray matter (GM) loss in schizophrenia. Subgroup 1 (n=2,622) was characterized by an early cortical-predominant loss (ECL) with enlarged striatum, whereas subgroup 2 (n=1,600) displayed an early subcortical-predominant loss (ESL) in the hippocampus, amygdala, thalamus, brain stem and striatum. These reconstructed trajectories suggest that the GM volume reduction originates in the Broca's area/adjacent fronto-insular cortex for ECL and in the hippocampus/adjacent medial temporal structures for ESL. With longer disease duration, the ECL subtype exhibited a gradual worsening of negative symptoms and depression/anxiety, and less of a decline in positive symptoms. We confirmed the reproducibility of these imaging-based subtypes across various sample sites, independent of macroeconomic and ethnic factors that differed across these geographic locations, which include Europe, North America and East Asia. These findings underscore the presence of distinct pathobiological foundations underlying schizophrenia. This new imaging-based taxonomy holds the potential to identify a more homogeneous sub-population of individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors. Competing Interests: Competing Interests Statement Lena Palaniyappan reports personal fees from Janssen Canada, Otsuka Canada, SPMM Course Limited UK and the Canadian Psychiatric Association; book royalties from Oxford University Press; and investigator-initiated educational grants from Sunovion, Janssen Canada and Otsuka Canada, outside the submitted work. Tilo Kircher received unrestricted educational grants from Servier, Janssen, Recordati, Aristo, Otsuka, neuraxpharm. Philipp Homan has received grants and honoraria from Novartis, Lundbeck, Mepha, Janssen, Boehringer Ingelheim, Neurolite outside of this work. Ole A. Andreassen is a consultant to Cortechs.ai and received speakers honorarium from Lundbeck, Janssen, Sunovion. These interests played no role in the research reported here. Other authors disclose no conflict of interest.
Databáze:	MEDLINE
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