Twenty-four-hour ambulatory, but not clinic blood pressure associates with leptin in young adults with overweight or obesity: The African-PREDICT study.

Autor: van Niekerk E; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa., Botha-Le Roux S; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.; Medical Research Council: Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Mels CMC; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.; Medical Research Council: Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Swanepoel M; Physical activity, Sport and Recreation (PhASRec), North-West University, Potchefstroom, South Africa., Delles C; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Welsh P; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Kruger R; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa. Ruan.Kruger@nwu.ac.za.; Medical Research Council: Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. Ruan.Kruger@nwu.ac.za.
Jazyk: angličtina
Zdroj: Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2024 Feb; Vol. 47 (2), pp. 478-486. Date of Electronic Publication: 2023 Oct 23.
DOI: 10.1038/s41440-023-01477-7
Abstrakt: Hypertension and obesity are known pro-inflammatory conditions, and limited studies explored various blood pressure modalities and inflammatory markers in young adults with overweight or obesity (OW/OB). We assessed the relationship of clinic and 24 h ambulatory blood pressure with an array of inflammatory markers in young adults with OW/OB. This cross-sectional study included women and men of Black and White ethnicity (n = 1194) with a median age of 24.5 ± 3.12 years. Participants were divided into normal weight and OW/OB groups according to body mass index. Clinic and 24 h ambulatory systolic and diastolic blood pressure were measured. Inflammatory markers included leptin, interleukin-6, interleukin-8, tumour necrosis factor-α, adiponectin, interleukin-10, and C-reactive protein. After adjustments for age, sex, and ethnicity, the OW/OB group had higher blood pressure and an overall worse inflammatory profile compared to the normal weight group (all p ≤ 0.024). In the OW/OB group, 24 h systolic (r = 0.22; p < 0.001) and diastolic blood pressure (r = 0.28; p < 0.001) correlated with leptin, independent of age, sex, and ethnicity. In fully adjusted regression models, 24 h systolic blood pressure (adj.R 2  = 0.25; β = 0.28; p = 0.035) and diastolic blood pressure (adj.R 2  = 0.10; β = 0.32; p = 0.034), associated with leptin in the OW/OB group and significance remained with additional adjustments for visceral adiposity index. Twenty-four-hour ambulatory, but not clinic blood pressure, is related to leptin in young adults with OW/OB. Leptin shows a stronger relationship with adiposity when compared to other inflammatory markers and may play a role in subcutaneous adiposity-related increased blood pressure.
(© 2023. The Author(s).)
Databáze: MEDLINE
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