Human diet-derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization.

Autor: Hu Q; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; Department of Pharmacy, Chinese PLA General Hospital, Beijing, China., Zhang W; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Wei F; School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Huang M; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China., Shu M; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Song D; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Wen J; School of Food and Bioengineering, Xihua University, Chengdu, China., Wang J; Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China., Nian Q; Department of Blood Transfusion, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China., Ma X; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zeng J; School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.; Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zhao Y; Department of Pharmacy, Chinese PLA General Hospital, Beijing, China.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2024 Jan; Vol. 38 (1), pp. 280-304. Date of Electronic Publication: 2023 Oct 23.
DOI: 10.1002/ptr.8043
Abstrakt: This review focuses on the potential ameliorative effects of polyphenolic compounds derived from human diet on hepatic diseases. It discusses the molecular mechanisms and recent advancements in clinical applications. Edible polyphenols have been found to play a therapeutic role, particularly in liver injury, liver fibrosis, NAFLD/NASH, and HCC. In the regulation of liver injury, polyphenols exhibit anti-inflammatory and antioxidant effects, primarily targeting the TGF-β, NF-κB/TLR4, PI3K/AKT, and Nrf2/HO-1 signaling pathways. In the regulation of liver fibrosis, polyphenolic compounds effectively reverse the fibrotic process by inhibiting the activation of hepatic stellate cells (HSC). Furthermore, polyphenolic compounds show efficacy against NAFLD/NASH by inhibiting lipid oxidation and accumulation, mediated through the AMPK, SIRT, and PPARγ pathways. Moreover, several polyphenolic compounds exhibit anti-HCC activity by suppressing tumor cell proliferation and metastasis. This inhibition primarily involves blocking Akt and Wnt signaling, as well as inhibiting the epithelial-mesenchymal transition (EMT). Additionally, clinical trials and nutritional evidence support the notion that certain polyphenols can improve liver disease and associated metabolic disorders. However, further fundamental research and clinical trials are warranted to validate the efficacy of dietary polyphenols.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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