The role of leptomeningeal collaterals in redistributing blood flow during stroke.

Autor: Epp R; Institute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland., Glück C; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Binder NF; Deptartment of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., El Amki M; Deptartment of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Weber B; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Wegener S; Deptartment of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Jenny P; Institute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland., Schmid F; Institute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland.; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.
Jazyk: angličtina
Zdroj: PLoS computational biology [PLoS Comput Biol] 2023 Oct 23; Vol. 19 (10), pp. e1011496. Date of Electronic Publication: 2023 Oct 23 (Print Publication: 2023).
DOI: 10.1371/journal.pcbi.1011496
Abstrakt: Leptomeningeal collaterals (LMCs) connect the main cerebral arteries and provide alternative pathways for blood flow during ischaemic stroke. This is beneficial for reducing infarct size and reperfusion success after treatment. However, a better understanding of how LMCs affect blood flow distribution is indispensable to improve therapeutic strategies. Here, we present a novel in silico approach that incorporates case-specific in vivo data into a computational model to simulate blood flow in large semi-realistic microvascular networks from two different mouse strains, characterised by having many and almost no LMCs between middle and anterior cerebral artery (MCA, ACA) territories. This framework is unique because our simulations are directly aligned with in vivo data. Moreover, it allows us to analyse perfusion characteristics quantitatively across all vessel types and for networks with no, few and many LMCs. We show that the occlusion of the MCA directly caused a redistribution of blood that was characterised by increased flow in LMCs. Interestingly, the improved perfusion of MCA-sided microvessels after dilating LMCs came at the cost of a reduced blood supply in other brain areas. This effect was enhanced in regions close to the watershed line and when the number of LMCs was increased. Additional dilations of surface and penetrating arteries after stroke improved perfusion across the entire vasculature and partially recovered flow in the obstructed region, especially in networks with many LMCs, which further underlines the role of LMCs during stroke.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Epp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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