Wait and see: a case of EBV + cutaneous extranodal NK/T-type lymphoma with indolent behaviour.

Autor: Aromolo IF; Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, 20122, Milan, Italy. italo.aromolo@unimi.it.; Department of Pathophysiology and Transplantation, Università Degli Studi Di Milano, Milan, Italy. italo.aromolo@unimi.it., Pescia C; Department of Pathophysiology and Transplantation, Università Degli Studi Di Milano, Milan, Italy.; Pathology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Simeoli D; Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, 20122, Milan, Italy.; Department of Pathophysiology and Transplantation, Università Degli Studi Di Milano, Milan, Italy., Violetti SA; Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, 20122, Milan, Italy.; Department of Pathophysiology and Transplantation, Università Degli Studi Di Milano, Milan, Italy., Ferla V; Hematology and Bone Marrow Transplant Unit, IRCCS Ospedale San Raffaele, Milan, Italy., Rossi FG; Division of Hematology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Croci GA; Pathology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2024 Jun; Vol. 484 (6), pp. 1029-1032. Date of Electronic Publication: 2023 Oct 23.
DOI: 10.1007/s00428-023-03681-9
Abstrakt: Extranodal NK/T-cell lymphoma (ENKTL) is a rare lymphoma subtype associated with Epstein-Barr virus (EBV) infection, portending a poor prognosis despite systemic chemotherapy. We present the unusual case of an 85-year-old man receiving ibrutinib for mantle cell lymphoma, who developed a erythematous, subcutaneous nodule on the forehead, featuring a proliferation of pleomorphic CD8 + /CD56 - /EBV + cells. Given the negative staging and comorbidities, a watchful waiting strategy was performed, experiencing a benign course with self-resolution and complete remission over a 4-year follow-up. The literature on primary cutaneous ENKTL has been discussed, with particular attention to clinical and histological prognostic factors.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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