The future of evolutionary medicine: sparking innovation in biomedicine and public health.

Autor:	Natterson-Horowitz B; Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, United States., Aktipis A; Department of Psychology, Arizona State University, Tempe, AZ, United States.; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, United States., Fox M; Department of Anthropology, University of California, Los Angeles, Los Angeles, CA, United States.; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States., Gluckman PD; Koi Tū: The Centre for Informed Futures, University of Auckland, Auckland, New Zealand.; Liggins Institute, University of Auckland, Auckland, New Zealand., Low FM; Koi Tū: The Centre for Informed Futures, University of Auckland, Auckland, New Zealand., Mace R; Department of Anthropology, University College London, London, United Kingdom., Read A; Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, State College, PA, United States.; Department of Entomology, The Pennsylvania State University, State College, PA, United States.; Huck Institutes of the Life Sciences, The Pennsylvania State University, State College, PA, United States., Turner PE; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, United States.; Program in Microbiology, Yale School of Medicine, New Haven, CT, United States., Blumstein DT; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in science [Front Sci] 2023; Vol. 1. Date of Electronic Publication: 2023 Feb 28.
DOI:	10.3389/fsci.2023.997136
Abstrakt:	Evolutionary medicine - i.e. the application of insights from evolution and ecology to biomedicine - has tremendous untapped potential to spark transformational innovation in biomedical research, clinical care and public health. Fundamentally, a systematic mapping across the full diversity of life is required to identify animal model systems for disease vulnerability, resistance, and counter-resistance that could lead to novel clinical treatments. Evolutionary dynamics should guide novel therapeutic approaches that target the development of treatment resistance in cancers (e.g., via adaptive or extinction therapy) and antimicrobial resistance (e.g., via innovations in chemistry, antimicrobial usage, and phage therapy). With respect to public health, the insight that many modern human pathologies (e.g., obesity) result from mismatches between the ecologies in which we evolved and our modern environments has important implications for disease prevention. Life-history evolution can also shed important light on patterns of disease burden, for example in reproductive health. Experience during the COVID-19 (SARS-CoV-2) pandemic has underlined the critical role of evolutionary dynamics (e.g., with respect to virulence and transmissibility) in predicting and managing this and future pandemics, and in using evolutionary principles to understand and address aspects of human behavior that impede biomedical innovation and public health (e.g., unhealthy behaviors and vaccine hesitancy). In conclusion, greater interdisciplinary collaboration is vital to systematically leverage the insight-generating power of evolutionary medicine to better understand, prevent, and treat existing and emerging threats to human, animal, and planetary health. Competing Interests: Conflict of interest PT is co-founder of Felix Biotechnology Inc., and declares a financial interest in this company that seeks to commercially develop phages for use as therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Databáze:	MEDLINE
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